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Biocompatible gels of chitosan–buriti oil for potential wound healing applications

2020Journal article Open access
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dc.contributor.authorFerreira, Maria Onaira Gonçalves
dc.contributor.authorLima, Idglan Sá
dc.contributor.authorRibeiro, Alessandra Braga
dc.contributor.authorLobo, Anderson O.
dc.contributor.authorRizzo, Marcia S.
dc.contributor.authorOsajima, Josy Anteveli
dc.contributor.authorSilva-Filho, Edson C.
dc.date.accessioned2020-05-08T15:00:21Z
dc.date.available2020-05-08T15:00:21Z
dc.date.issued2020
dc.description.abstractThe buriti oil (Mauritia flexuosa L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the e ect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory and healing e ects were also investigated. Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified. The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan and oil) proved to be e cient against Staphylococcus aureus and Klebsiella pneumonia at the 10 mg/mL. Similar behavior was observed for antioxidant activity, determined by the -carotene bleaching assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity, which may be related to the inhibition of the release of free radicals. Regarding wound healing performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete wound retraction. The results indicated that the gel chitosan–buriti oil has a set of properties that improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to treat skin lesions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, M. O. G., Lima, I. S., Ribeiro, A. B., Lobo, A. O., Rizzo, M. S., Osajima, J. A., ...Silva-Filho, E. C. (2020). Biocompatible gels of chitosan–buriti oil for potential wound healing applications. Materials, 13(8), 1977pt_PT
dc.identifier.doi10.3390/ma13081977pt_PT
dc.identifier.eid85084862250
dc.identifier.issn1996-1944
dc.identifier.pmcPMC7215912
dc.identifier.pmid32340366
dc.identifier.urihttp://hdl.handle.net/10400.14/30543
dc.identifier.wos000531829000181
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolysaccharidespt_PT
dc.subjectBiologicalpt_PT
dc.subjectHealingpt_PT
dc.titleBiocompatible gels of chitosan–buriti oil for potential wound healing applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.titleMaterialspt_PT
oaire.citation.volume13pt_PT
person.familyNameRibeiro
person.familyNameLobo
person.familyNameOsajima
person.familyNameRodrigues-Filho
person.givenNameAlessandra Braga
person.givenNameAnderson
person.givenNameJosy
person.givenNameEdson
person.identifierS-5277-2018
person.identifier114239
person.identifier.ciencia-id591B-EA9A-153F
person.identifier.orcid0000-0003-3822-8601
person.identifier.orcid0000-0002-2544-0438
person.identifier.orcid0000-0001-7089-3244
person.identifier.orcid0000-0003-4305-0326
person.identifier.ridS-5277-2018
person.identifier.ridB-2893-2011
person.identifier.ridC-5024-2009
person.identifier.scopus-author-id55765010500
person.identifier.scopus-author-id14019685200
person.identifier.scopus-author-id16507501000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication384e4601-e7c9-485f-b7f9-6ae468144d0c
relation.isAuthorOfPublication071853e4-9c15-4549-a681-e7edd44fb6f4
relation.isAuthorOfPublication71007aa5-8a12-488f-9610-273b45cc5741
relation.isAuthorOfPublication31a1866f-4dc9-4d4b-9b79-9d86846f5704
relation.isAuthorOfPublication.latestForDiscovery071853e4-9c15-4549-a681-e7edd44fb6f4

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