Publicação
The role of unsaturated fatty acid-rich dairy products in adipocyte metabolism
| dc.contributor.author | Machado, Manuela | |
| dc.contributor.author | Costa, Eduardo M. | |
| dc.contributor.author | Silva, Sara | |
| dc.contributor.author | Gomes, Ana Maria | |
| dc.contributor.author | Pintado, Manuela | |
| dc.date.accessioned | 2024-12-09T15:33:10Z | |
| dc.date.available | 2024-12-09T15:33:10Z | |
| dc.date.issued | 2024-11-21 | |
| dc.description.abstract | This study investigated the fatty acid profile, permeability, and metabolic effects of a functional yogurt enriched with pomegranate oil, focusing on its impact on lipid metabolism and inflammatory responses. The yogurt’s fatty acid composition was primarily composed of long-chain polyunsaturated fatty acids (54.37%), followed by saturated (29.34%) and monounsaturated fatty acids (16.36%). During in vitro digestion, a shift in fatty acid profile was observed, with a decrease in polyunsaturated and saturated fatty acids and a slight increase in monounsaturated fatty acids due to hydrolysis. This study further analyzed fatty acid permeability across Caco-2/HT29-MTX monolayers and 3T3-L1 cell uptake, revealing higher permeability for saturated fatty acids than unsaturated ones. In 3T3-L1 cells, permeated fatty acids induced higher lipolysis and increased adiponectin secretion without affecting leptin levels. Cytokine analysis indicated a decrease in pro-inflammatory markers, such as MCP-1, and a significant increase in anti-inflammatory cytokines like IL-10, suggesting potential benefits in reducing obesity-related inflammation. These results underscore the role of functional yogurts enriched with polyunsaturated fatty acids as promising agents for modulating lipid metabolism and inflammatory responses. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/molecules29235502 | pt_PT |
| dc.identifier.eid | 85211938221 | |
| dc.identifier.issn | 1420-3049 | |
| dc.identifier.pmid | 39683663 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/47464 | |
| dc.identifier.wos | 001376364800001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Fatty acid permeability | pt_PT |
| dc.subject | Adipocyte metabolism | pt_PT |
| dc.subject | Inflammatory cytokines | pt_PT |
| dc.subject | Functional food | pt_PT |
| dc.title | The role of unsaturated fatty acid-rich dairy products in adipocyte metabolism | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 23 | pt_PT |
| oaire.citation.title | Molecules | pt_PT |
| oaire.citation.volume | 29 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |