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Current state on the development of nanoparticles for use against bacterial gastrointestinal pathogens: focus on chitosan nanoparticles loaded with phenolic compounds

2015Journal article Restricted access
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dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorPereira, Adriana
dc.contributor.authorPintado, Manuela
dc.date.accessioned2016-01-07T15:46:18Z
dc.date.available2016-01-07T15:46:18Z
dc.date.issued2015
dc.description.abstractGastrointestinal diseases have a huge impact especially in third world countries, making it urgent to seek new effective antimicrobial therapies. Thus, the development of nanoparticles (NPs) with bioactive compounds having antimicrobial activity has been the target of research over the past years. The development of antimicrobial drug NPs may be promising to overcome the problems associated with antibiotic resistance caused by many pathogenic bacteria. Moreover, the NPs administration of antimicrobial agents has advantages associated therewith, as use of low cost materials, contribution to the improvement of the therapeutic index and a controlled release drug by increasing the pharmacokinetics. These systems can be used to specific strains of bacteria, and to release interesting antimicrobial compounds. The phenolic compounds (PC) are a class of such bioactive compounds for which their antimicrobial activity was already tested on the production of NPs. Polymeric or lipidic NPs systems have been investigated to deliver these compounds. Chitosan is a polymer widely known for their properties, especially the antimicrobial activity and its ability to adhere to intestinal epithelium. This review article aims to evaluate and discuss recent developments in PC new delivery systems with antimicrobial activity against gastrointestinal pathogens, their production processes, activities, focusing on NPs produced using chitosan as the main structural and functional material.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationMADUREIRA, Ana Raquel; PEREIRA, Adriana; PINTADO, M.E. - Current state on the development of nanoparticles for use against bacterial gastrointestinal pathogens. Focus on chitosan nanoparticles loaded with phenolic compounds. Carbohydrate Polymers. ISSN 0144-8617. Vol. 130 (2015), p. 429–439pt_PT
dc.identifier.doi10.1016/j.carbpol.2015.05.030pt_PT
dc.identifier.eid84931007185
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.pmid26076644
dc.identifier.urihttp://hdl.handle.net/10400.14/18848
dc.identifier.wos000357244900051
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectNanoparticlespt_PT
dc.subjectChitosanpt_PT
dc.subjectPolyphenolspt_PT
dc.subjectGastrointestinal diseasespt_PT
dc.titleCurrent state on the development of nanoparticles for use against bacterial gastrointestinal pathogens: focus on chitosan nanoparticles loaded with phenolic compoundspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-ALI%2F117808%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F71391%2F2010/PT
oaire.citation.endPage439
oaire.citation.startPage429
oaire.citation.titleCarbohydrate Polymers
oaire.citation.volume130
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameMadureira
person.familyNameMiranda de Castro
person.givenNameRaquel
person.givenNamePedro João
person.identifierM-4659-2013
person.identifier.ciencia-id1C14-25F8-CC07
person.identifier.ciencia-id5112-6B99-DC1F
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0001-7164-8005
person.identifier.ridM-4659-2013
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id57201808340
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd33a1d99-423e-4ecd-ae9e-b3e46262b521
relation.isAuthorOfPublication99909754-7408-4e67-8f02-9cdb3c5a88d4
relation.isAuthorOfPublication.latestForDiscoveryd33a1d99-423e-4ecd-ae9e-b3e46262b521
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