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Wild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteria

2014Journal article Open access
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dc.contributor.authorAlves, Maria José
dc.contributor.authorFerreira, I.C.F.R.
dc.contributor.authorLourenço, I.
dc.contributor.authorCastro, A.
dc.contributor.authorPereira, L.
dc.contributor.authorMartins, A.
dc.contributor.authorPintado, M.
dc.date.accessioned2015-05-12T15:17:05Z
dc.date.available2015-05-12T15:17:05Z
dc.date.issued2014
dc.description.abstractAims: The main objective of this study was to evaluate the capacity of wild mushroom extracts to potentiate the action of standard antibiotics, through synergisms that allow a decrease in their therapeutic doses and ultimately contribute to the reduction of resistances. Methods and Results: Wild mushroom extracts were applied to different multiresistant micro-organisms (Escherichia coli, extended-spectrum betalactamase- producing (ESBL) E. coli and methicillin-resistant Staphylococcus aureus (MRSA), combined with commercial antibiotics (penicillin, ampicillin, amoxicillin/clavulanic acid, cefoxitin, ciprofloxacin, cotrimoxazol, levofloxacin). Microdilution method was used to determine minimum inhibitory concentrations (MICs). The results obtained showed higher synergistic effects against MRSA than against E. coli. Mycena rosea and Fistulina hepatica were the best extracts for synergistic effects against MRSA. The efficiency of Russula delica extract against E. coli 1 (resistant to ampicillin, ciprofloxacin and trimethoprim/sulfasoxazole) and E. coli 2 (resistant to amoxicillin/clavulanic acid and ampicillin) was higher than that of Leucopaxillus giganteus extract; nevertheless, the latter extract exhibited better synergistic effects against ESBL E. coli. Conclusions: This study shows that, similarly to plants, some mushroom extracts can potentiate the action of antibiotics extensively used in clinical practice for Gram-positive or Gram-negative bacteria, with positive action even against multiresistant bacteria. Significance and Impact of the Study: Mushroom extracts could decrease therapeutic doses of standard antibiotics and reduce micro-organism’s resistance to those drugs.por
dc.description.versioninfo:eu-repo/semantics/acceptedVersion
dc.identifier.citationALVES, Maria José …[et al.] - Wild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteria. Journal of Applied Microbiology. ISSN 1365-2672. Vol. 116, n.º 1 (2014), p. 32-38por
dc.identifier.doi10.1111/jam.12348
dc.identifier.eid84890429677
dc.identifier.pmid24107088
dc.identifier.urihttp://hdl.handle.net/10400.14/17574
dc.identifier.wosWOS:000328284000004
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWiley
dc.relationPortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectAntibioticspor
dc.subjectMultiresistant bacteriapor
dc.subjectSynergismpor
dc.subjectWild mushroom extractspor
dc.titleWild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteriapor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePortuguese Wild Mushrooms: Chemical characterization and functional study of antiproliferative and proapoptotic properties in cancer cell lines
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FAGR-ALI%2F110062%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.citation.endPage38
oaire.citation.startPage32
oaire.citation.titleJournal of Applied Microbiology
oaire.citation.volume116
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFerreira
person.familyNameCastro
person.familyNameMartins
person.familyNamePintado
person.givenNameIsabel
person.givenNameAna Isabel
person.givenNameAnabela
person.givenNameMaria Manuela
person.identifier144781
person.identifier456608
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id7B18-A810-6B93
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0001-9069-5851
person.identifier.orcid0000-0001-6218-4413
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridE-8500-2013
person.identifier.ridM-3493-2017
person.identifier.ridG-5488-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id7402832529
person.identifier.scopus-author-id7203013518
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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