Advisor(s)
Abstract(s)
Aims: The main objective of this study was to evaluate the capacity of wild
mushroom extracts to potentiate the action of standard antibiotics, through
synergisms that allow a decrease in their therapeutic doses and ultimately
contribute to the reduction of resistances.
Methods and Results: Wild mushroom extracts were applied to different
multiresistant micro-organisms (Escherichia coli, extended-spectrum betalactamase-
producing (ESBL) E. coli and methicillin-resistant Staphylococcus
aureus (MRSA), combined with commercial antibiotics (penicillin, ampicillin,
amoxicillin/clavulanic acid, cefoxitin, ciprofloxacin, cotrimoxazol, levofloxacin).
Microdilution method was used to determine minimum inhibitory
concentrations (MICs). The results obtained showed higher synergistic effects
against MRSA than against E. coli. Mycena rosea and Fistulina hepatica were
the best extracts for synergistic effects against MRSA. The efficiency of Russula
delica extract against E. coli 1 (resistant to ampicillin, ciprofloxacin and
trimethoprim/sulfasoxazole) and E. coli 2 (resistant to amoxicillin/clavulanic
acid and ampicillin) was higher than that of Leucopaxillus giganteus extract;
nevertheless, the latter extract exhibited better synergistic effects against ESBL
E. coli.
Conclusions: This study shows that, similarly to plants, some mushroom
extracts can potentiate the action of antibiotics extensively used in clinical
practice for Gram-positive or Gram-negative bacteria, with positive action even
against multiresistant bacteria.
Significance and Impact of the Study: Mushroom extracts could decrease
therapeutic doses of standard antibiotics and reduce micro-organism’s
resistance to those drugs.
Description
Keywords
Antibiotics Multiresistant bacteria Synergism Wild mushroom extracts
Citation
ALVES, Maria José …[et al.] - Wild mushroom extracts potentiate the action of standard antibiotics against multiresistant bacteria. Journal of Applied Microbiology. ISSN 1365-2672. Vol. 116, n.º 1 (2014), p. 32-38
Publisher
Wiley