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Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping

2010Journal article Open access
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dc.contributor.authorPiloto, N.
dc.contributor.authorTeixeira, HM
dc.contributor.authorGarrido, P.
dc.contributor.authorTeixeira-Lemos, E.
dc.contributor.authorTeixeira, M.
dc.contributor.authorParada, B.
dc.contributor.authorSereno, J.
dc.contributor.authorPinto, R .
dc.contributor.authorAlves, R.
dc.contributor.authorSantos, P.
dc.contributor.authorRomão, AM
dc.contributor.authorNunes, S.
dc.contributor.authorNeto, P.
dc.contributor.authorCarvalho, L.
dc.contributor.authorCouceiro, P.
dc.contributor.authorXavier, F.
dc.contributor.authorRocha-Pereira, P.
dc.contributor.authorCosta, Elísio
dc.contributor.authorBelo, L.
dc.contributor.authorSantos-Silva, A.
dc.contributor.authorTeixeira, F.
dc.contributor.authorReis, F.
dc.date.accessioned2011-06-03T14:25:18Z
dc.date.available2011-06-03T14:25:18Z
dc.date.issued2010
dc.description.abstractRecombinant human erythropoietin (rhEPO) has been therapeutically used for correction of anaemia. However, due to the increase in circulating red blood cells (RBCs) it promotes, thus increasing oxygen delivery to muscles and improving performance in sport, it has been also illegally used as sports doping. Besides the well known increase of hematocrit and blood viscosity; which might cause serious complications for the athletes, other disturbances could occur, whose mechanisms remain to be fully elucidated. This study aimed to evaluate the hemorheological and cardiovascular effects of administration of rhEPO to rats under chronic aerobic exercise. A ten week-protocol was performed in four male Wistar rat groups: control — sedentary; rhEPO — 50 IV/kg, 3 times/wk; exercised (EX) — swimming for 1 hr, 3 times/ wk; EX+rhEPO. rhEPO in trained rats promoted erythrocyte count increase, hypertension, heart hypertro-phy, sympathetic and serotonergic overactivation, as well as a trend to increased oxidative stress. In conclusion, rhEPO doping in rats under chronic exercise promotes not only the expected increased hematocrit, but also other serious deleterious cardiovascular and thromboembolic modifications, including live risk, which might be known and assumed by all sports authorities, including athletes and their physicians.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationPILOTO, N... [et al.] - Hemorheological and cardiovascular effects of erythropoietin in a rat model of sports doping. Boletim Sociedade da Portuguesa de Hemorreologia e Microcirculação. ISSN 0872-4938.Vol. 25, n.º 1 (2010), p. 11 - 22.por
dc.identifier.issn0872-4938
dc.identifier.urihttp://hdl.handle.net/10400.14/4375
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSociedade Portuguesa de Hemorreologia e Microcirculaçãopor
dc.subjectrhEPOpor
dc.subjectDopingpor
dc.subjectChronic aerobic exercisepor
dc.subjectHemorheological and cardiovascular (effects)por
dc.titleHemorheological and cardiovascular effects of erythropoietin in a rat model of sports dopingpor
dc.title.alternativeEfeitos hemorreológicos e cardiovasculares da eritropoietina num modelo de rato em exercício físico sob a acção de drogaspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage22
oaire.citation.issue1
oaire.citation.startPage11
oaire.citation.titleBoletim Sociedade da Portuguesa de Hemorreologia e Microcirculação
oaire.citation.volume25
person.familyNameBelo
person.givenNameLuís
person.identifier.ciencia-idC319-EED1-E15D
person.identifier.orcid0000-0002-3941-6850
person.identifier.ridK-5878-2013
person.identifier.scopus-author-id6602879850
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication3654b7b5-7ad2-4f2f-9114-93dc094f8e9e
relation.isAuthorOfPublication.latestForDiscovery3654b7b5-7ad2-4f2f-9114-93dc094f8e9e

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