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Topical application of probiotics in skin: adhesion, antimicrobial and antibiofilm in vitro assays

2017Journal article Restricted access
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dc.contributor.authorLopes, E. G.
dc.contributor.authorMoreira, D. A.
dc.contributor.authorGullón, P.
dc.contributor.authorGullón, B.
dc.contributor.authorCardelle-Cobas, A.
dc.contributor.authorTavaria, F. K.
dc.date.accessioned2017-10-17T09:20:06Z
dc.date.available2017-10-17T09:20:06Z
dc.date.issued2017
dc.description.abstractAims: When skin dysbiosis occurs as a result of skin disorders, probiotics can act as modulators, restoring microbial balance. Several properties of selected probiotics were evaluated so that their topical application could be considered. Methods and Results: Adhesion, antimicrobial, quorum sensing and antibiofilm assays were carried out with several probiotic strains and tested against selected skin pathogens. All tested strains displayed significant adhesion to keratin. All lactobacilli with the exception of Lactobacillus delbrueckii, showed antimicrobial activity against skin pathogens, mainly due to organic acid production. Most of them also prevented biofilm formation, but only Propioniferax innocua was able to break down mature biofilms. Conclusions: This study demonstrates that although all tested probiotics adhered to human keratin, they showed limited ability to prevent adhesion of some potential skin pathogens. Most of the tested probiotics successfully prevented biofilm formation, suggesting that they may be successfully used in the future as a complement to conventional therapies in the treatment of a range of skin disorders. Significance and Impact of study: The topically used probiotics may be a natural, targeted treatment approach to several skin disorders and a complement to conventional therapies which present many undesirable side effects.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLOPES, E.G.; MOREIRA, D.A.; GULLÓN, Beatriz; GULLÓN, Patricia; CARDELLE-COBAS, A.; TAVARIA, Freni - Topical application of probiotics in skin: adhesion, antimicrobial and antibiofilm in vitro assays. Journal of Applied Microbiology. ISSN 1364-5072. Vol. 122 (2017), p. 450-461pt_PT
dc.identifier.doi10.1111/jam.13349pt_PT
dc.identifier.eid85009204476
dc.identifier.eissn1365-2672
dc.identifier.issn1364-5072
dc.identifier.pmid27862685
dc.identifier.urihttp://hdl.handle.net/10400.14/23134
dc.identifier.wos000393883100013
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley
dc.subjectAntimicrobialspt_PT
dc.subjectBiofilmspt_PT
dc.subjectProbioticspt_PT
dc.subjectQuorum sensingpt_PT
dc.subjectStaphylococcipt_PT
dc.titleTopical application of probiotics in skin: adhesion, antimicrobial and antibiofilm in vitro assayspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FBBB-BIO%2F1113%2F2013/PT
oaire.citation.endPage461
oaire.citation.issue2
oaire.citation.startPage450
oaire.citation.titleJournal of Applied Microbiologypt_PT
oaire.citation.volume122
oaire.fundingStream5876
oaire.fundingStream3599-PPCDT
person.familyNameGullón Estévez
person.familyNameKekhasharú Tavaria
person.givenNameBeatriz
person.givenNameFreni
person.identifier.ciencia-idED13-E1EA-EC0F
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.orcid0000-0002-2529-1348
person.identifier.orcid0000-0002-6273-6668
person.identifier.scopus-author-id6503889474
person.identifier.scopus-author-id6602645613
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1ab90ef8-ff40-4884-8910-26867a3c16fb
relation.isAuthorOfPublicatione42f563a-5b1e-4586-b302-efabe7ce07da
relation.isAuthorOfPublication.latestForDiscoverye42f563a-5b1e-4586-b302-efabe7ce07da
relation.isProjectOfPublication3fe5970e-de39-42f7-a29d-18521b591a09
relation.isProjectOfPublication99bfbf01-8673-433b-81ae-89d487807161
relation.isProjectOfPublication.latestForDiscovery99bfbf01-8673-433b-81ae-89d487807161

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