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Molecular evidence of the close relatedness of clinical, gull and wastewater isolates of quinolone-resistant Escherichia coli

2015Journal article Restricted access
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dc.contributor.authorVarela, Ana Rita
dc.contributor.authorManageiro, Vera
dc.contributor.authorFerreira, Eugénia
dc.contributor.authorAugusta Guimarães, M.
dc.contributor.authorCosta, Paulo Martins da
dc.contributor.authorCaniça, Manuela
dc.contributor.authorManaia, Célia M.
dc.date.accessioned2016-04-21T08:45:28Z
dc.date.available2016-04-21T08:45:28Z
dc.date.issued2015
dc.description.abstractEscherichia coli with reduced susceptibility to quinolones isolated from different environmental sources (urban wastewater treatment plants, n = 61; hospital effluent, n = 10; urban streams, n = 9; gulls, n = 18; birds of prey, n = 17) and from hospitalised patients (n = 28) were compared based on multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). The habitats with the most diversified genotypes of quinolone-resistant E. coli, corresponding to the highest genetic diversity (H'), were wastewater and gulls. In addition, genetically distinct populations were observed in clinical samples and birds of prey, suggesting the influence of the habitat or selective pressures on quinolone-resistant E. coli. The close genetic relatedness between isolates of clinical origin and from gulls and wastewater suggests the existence of potential routes of propagation between these sources. The most common sequence types were ST131 and ST10, with ST131 being highly specific to patients, although distributed in all of the other habitats except birds of prey. The prevalence of antimicrobial resistance was significantly higher in isolates from patients and gulls than from other sources (P < 0.01), suggesting that the effect of selective pressures met by isolates subjected to strong human impacts. The evidence presented suggests the potential circulation of bacteria between the environmental and clinical compartments, with gulls being a relevant vector of bacteria and resistance genes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationVARELA, Ana Rita; MANAGEIRO, Vera; FERREIRA, Eugénia; GUIMARÃES, M. Augusta; COSTA, Paulo Martins da Costa; CANIÇA, Manuela; MANAIA, C. M. …[et al.] - Molecular evidence of the close relatedness of clinical, gull and wastewater isolates of quinolone-resistant Escherichia coli. Journal of Global Antimicrobial Resistance. ISSN 22137165. Vol. 3, n.º 4 (2015), p. 286-289 http://dx.doi.org/10.1016/j.jgar.2015.07.008 [short communication]pt_PT
dc.identifier.doi10.1016/j.jgar.2015.07.008pt_PT
dc.identifier.eid84946773838
dc.identifier.eissn2213-7173
dc.identifier.issn2213-7165
dc.identifier.pmid27842875
dc.identifier.urihttp://hdl.handle.net/10400.14/19866
dc.identifier.wos000366948100011
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.relationDYNAMICS OF ANTIMICROBIAL RESISTANCE BETWEEN THE HOSPITAL AND THE ENVIRONMENT
dc.relationTRACKING ANTIBIOTIC RESISTANCE FROM HOSPITAL EFFLUENTS TO THE SURROUNDING ENVIRONMENT
dc.relationEVOLUTIONARY POTENTIAL OF OXYIMINO-BETA-LACTAM RESISTANCE DETERMINANTS IN ANIMALS AND IDENTIFICATION OF NEW ENZYME-INHIBITORS FOR VETERINARY USE
dc.subjectQuinolone resistancept_PT
dc.subjectWildlifept_PT
dc.subjectWastewaterpt_PT
dc.subjectHospitalpt_PT
dc.subjectMLSTpt_PT
dc.subjectPFGEpt_PT
dc.titleMolecular evidence of the close relatedness of clinical, gull and wastewater isolates of quinolone-resistant Escherichia colipt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDYNAMICS OF ANTIMICROBIAL RESISTANCE BETWEEN THE HOSPITAL AND THE ENVIRONMENT
oaire.awardTitleTRACKING ANTIBIOTIC RESISTANCE FROM HOSPITAL EFFLUENTS TO THE SURROUNDING ENVIRONMENT
oaire.awardTitleEVOLUTIONARY POTENTIAL OF OXYIMINO-BETA-LACTAM RESISTANCE DETERMINANTS IN ANIMALS AND IDENTIFICATION OF NEW ENZYME-INHIBITORS FOR VETERINARY USE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAAC-AMB%2F113840%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70986%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F77486%2F2011/PT
oaire.citation.endPage289
oaire.citation.issue4
oaire.citation.startPage286
oaire.citation.titleJournal of global antimicrobial resistance
oaire.citation.volume3
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameVarela
person.familyNameManageiro
person.familyNameFerreira
person.familyNameMartins da Costa
person.familyNameCaniça
person.familyNameManaia
person.givenNameAna Rita
person.givenNameVera
person.givenNameEugénia
person.givenNamePaulo
person.givenNameManuela
person.givenNameCélia
person.identifier223943
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person.identifier.ciencia-id3517-834C-6370
person.identifier.ciencia-idA719-DBA5-3A4B
person.identifier.ciencia-idC31F-553B-6365
person.identifier.orcid0000-0001-9691-0217
person.identifier.orcid0000-0001-7729-4199
person.identifier.orcid0000-0002-0765-3931
person.identifier.orcid0000-0001-6115-8811
person.identifier.orcid0000-0002-2077-6231
person.identifier.orcid0000-0002-3674-1789
person.identifier.ridM-9226-2013
person.identifier.ridC-3080-2014
person.identifier.ridH-3759-2016
person.identifier.scopus-author-id16480778900
person.identifier.scopus-author-id7103156990
person.identifier.scopus-author-id56372529300
person.identifier.scopus-author-id6701714717
person.identifier.scopus-author-id6602465318
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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