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Chitosan nanoparticles as alternative anti-staphylococci agents: bactericidal, antibiofilm and antiadhesive effects

2017Journal article Restricted access
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dc.contributor.authorCosta, E. M.
dc.contributor.authorSilva, S.
dc.contributor.authorVicente, S.
dc.contributor.authorNeto, C.
dc.contributor.authorCastro, P. M.
dc.contributor.authorVeiga, M.
dc.contributor.authorMadureira, R.
dc.contributor.authorTavaria, F.
dc.contributor.authorPintado, M. M.
dc.date.accessioned2017-11-14T14:56:15Z
dc.date.available2017-11-14T14:56:15Z
dc.date.issued2017
dc.description.abstractChitosan is a biocompatible, bioactive, non-toxic polymer that due to these characteristics has been widely used as a carrier for targeted delivery of bioactive molecules. In recent years, and considering that chitosan has a strong antimicrobial potential, the scientific community's focus has shifted onto the possible antimicrobial activity of chitosan nanoparticles. With this in mind, the aim of this work was to produce low molecular weight chitosan nanoparticles, through the ionic gelation method and characterize their potential biological activity against three staphylococci (MSSA, MRSA and MRSE) in planktonic and sessile environments. The chitosan nanoparticles produced had an average size of 244 ± 12 nm, an average charge of 17.3 ± 1.4 mV and had a MIC of 1.25 mg/mL for all tested microorganisms. Bactericidal activity was only registered for MSSA and MRSA with the time-inhibition curves showing bactericidal activity within 1 h. Assays regarding chitosan nanoparticles' impact upon sessile populations showed that they were effective in preventing MRSE adhesion and highly effective in reducing MRSA and MSSA biofilm formation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta, E. M., Silva, S., Vicente, S. Neto, C., Castro, P.M., Veiga, M…, Pintado, M. E. (2017). Chitosan nanoparticles as alternative anti-staphylococci agents: Bactericidal, antibiofilm and antiadhesive effects. Materials Science and Engineering C., 79, 221-226pt_PT
dc.identifier.doi10.1016/j.msec.2017.05.047pt_PT
dc.identifier.eid85019112721
dc.identifier.eissn1873-0191
dc.identifier.issn0928-4931
dc.identifier.pmid28629011
dc.identifier.urihttp://hdl.handle.net/10400.14/23366
dc.identifier.wos000404704300028
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation17819
dc.relationTextile staining: Toward a greener and functional solution
dc.subjectChitosan nanoparticlespt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectAntiadhesivept_PT
dc.subjectAntibiofilmpt_PT
dc.subjectMRSApt_PT
dc.subjectMRSEpt_PT
dc.titleChitosan nanoparticles as alternative anti-staphylococci agents: bactericidal, antibiofilm and antiadhesive effectspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTextile staining: Toward a greener and functional solution
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F90867%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBDE%2F103957%2F2014/PT
oaire.citation.endPage226
oaire.citation.startPage221
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume79
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameCosta
person.familyNameSilva
person.familyNameCastro
person.familyNameVeiga
person.familyNameMadureira
person.familyNameKekhasharú Tavaria
person.familyNamePintado
person.givenNameEduardo
person.givenNameSara
person.givenNamePaula
person.givenNameMariana
person.givenNameRaquel
person.givenNameFreni
person.givenNameMaria Manuela
person.identifier1888852
person.identifier2013444
person.identifierM-4659-2013
person.identifier456608
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-id8E18-0AFF-BF6D
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.ciencia-id1C14-25F8-CC07
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0001-8268-2137
person.identifier.orcid0000-0001-8841-6606
person.identifier.orcid0000-0002-1815-3270
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridM-8241-2013
person.identifier.ridM-4659-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id55158300800
person.identifier.scopus-author-id7102781782
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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