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Third generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?

2022-01-22Artigo científico Acesso aberto
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dc.contributor.authorRocha, Jaqueline
dc.contributor.authorFerreira, Catarina
dc.contributor.authorMil-Homens, Dalila
dc.contributor.authorBusquets, Antonio
dc.contributor.authorFialho, Arsénio M.
dc.contributor.authorHenriques, Isabel
dc.contributor.authorGomila, Margarita
dc.contributor.authorManaia, Célia M.
dc.date.accessioned2022-02-03T15:48:35Z
dc.date.available2022-02-03T15:48:35Z
dc.date.issued2022-01-22
dc.description.abstractBackground Klebsiella pneumoniae are ubiquitous bacteria and recognized multidrug-resistant opportunistic pathogens that can be released into the environment, mainly through sewage, where they can survive even after wastewater treatment. A major question is if once released into wastewater, the selection of lineages missing clinically-relevant traits may occur. Wastewater (n = 25) and clinical (n = 34) 3(rd) generation cephalosporin-resistant K. pneumoniae isolates were compared based on phenotypic, genotypic and genomic analyses. Results Clinical and wastewater isolates were indistinguishable based on phenotypic and genotypic characterization. The analysis of whole genome sequences of 22 isolates showed that antibiotic and metal resistance or virulence genes, were associated with mobile genetic elements, mostly transposons, insertion sequences or integrative and conjugative elements. These features were variable among isolates, according to the respective genetic lineage rather than the origin. Conclusions It is suggested that once acquired, clinically relevant features of K. pneumoniae may be preserved in wastewater, even after treatment. This evidence highlights the high capacity of K. pneumoniae for spreading through wastewater, enhancing the risks of transmission back to humans.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1186/s12864-021-08279-6pt_PT
dc.identifier.eid85123476790
dc.identifier.issn1471-2164
dc.identifier.pmcPMC8783465
dc.identifier.pmid35065607
dc.identifier.urihttp://hdl.handle.net/10400.14/36589
dc.identifier.wos000745613900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectWastewaterpt_PT
dc.subjectClinicalpt_PT
dc.subjectKlebsiella pneumoniaept_PT
dc.subjectAntibiotic resistancept_PT
dc.subjectComparative genomicspt_PT
dc.titleThird generation cephalosporin-resistant Klebsiella pneumoniae thriving in patients and in wastewater: what do they have in common?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleBMC Genomicspt_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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