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Oral films as breakthrough tools for oral delivery of proteins/peptides

2015Journal article Restricted access
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dc.contributor.authorCastro, Pedro M.
dc.contributor.authorFonte, Pedro
dc.contributor.authorSousa, Flávia
dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorSarmento, Bruno
dc.contributor.authorPintado, Manuela E.
dc.date.accessioned2016-01-07T16:33:35Z
dc.date.available2016-01-07T16:33:35Z
dc.date.issued2015
dc.description.abstractTherapeutic proteins and peptides demonstrate unique, peerless, pharmacological characteristics such as high specificity to receptors and superior biological mimicking of physiological mechanisms, resulting in a better therapeutic index compared to conventional chemical-derived drugs. However, proteins also present inherent bioavailability limitations. Thus, this paper proposes several effective tools to improve protein/peptide drugs stability, permeability and pharmacokinetics with special emphasis on oral polymeric films as oral delivery platforms. Indeed, oral films present inherent characteristics that can greatly enhance biological performance of proteins and peptides and patient compliance along with other advantages that are critically discussed in this review. A rational choice of excipients addressed in and manufacture processes are also focused. In addition, possible toxicity issues to be overtaken and critical analysis regarding current market tendencies respecting oral films and protein/peptides along with future prospects are disclosed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationCASTRO, Pedro M.; Fonte, Pedro; Sousa, Flávia; Madureira, Ana Raquel; Sarmento, Bruno; Pintado, M. E. - Oral films as breakthrough tools for oral delivery of proteins/peptides. Journal of Controlled Release. ISSN 0168-3659. Vol. 211 (2015), p. 63–73pt_PT
dc.identifier.doi10.1016/j.jconrel.2015.05.258pt_PT
dc.identifier.eid84930945233
dc.identifier.eissn1873-4995
dc.identifier.issn0168-3659
dc.identifier.pmid25979328
dc.identifier.urihttp://hdl.handle.net/10400.14/18852
dc.identifier.wos000357049800008
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.subjectBioactive peptidespt_PT
dc.subjectBioactive proteinspt_PT
dc.subjectBioavailability enhancementpt_PT
dc.subjectOral deliverypt_PT
dc.subjectOral filmspt_PT
dc.subjectStabilitypt_PT
dc.titleOral films as breakthrough tools for oral delivery of proteins/peptidespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage73
oaire.citation.startPage63
oaire.citation.titleJournal of Controlled Release
oaire.citation.volume211
person.familyNameMiranda de Castro
person.familyNameFonte
person.familyNameSousa
person.familyNameMadureira
person.familyNameSarmento
person.familyNamePintado
person.givenNamePedro João
person.givenNamePedro
person.givenNameFlávia
person.givenNameRaquel
person.givenNameBruno
person.givenNameMaria Manuela
person.identifierM-4659-2013
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person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0001-7164-8005
person.identifier.orcid0000-0002-1115-9282
person.identifier.orcid0000-0001-6587-6175
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0001-5763-7553
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridK-3215-2013
person.identifier.ridM-4659-2013
person.identifier.ridJ-6265-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id57201808340
person.identifier.scopus-author-id55146900200
person.identifier.scopus-author-id56385224800
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id57194334236
person.identifier.scopus-author-id7004483898
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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