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Sardine roe as a source of lipids to produce liposomes

2020Journal article Open access
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dc.contributor.authorGuedes, Marta
dc.contributor.authorCosta-Pinto, Ana Rita
dc.contributor.authorGonçalves, Virgínia
dc.contributor.authorMoreira-Silva, Joana
dc.contributor.authorTiritan, Maria
dc.contributor.authorReis, Rui L.
dc.contributor.authorFerreira, Helena
dc.contributor.authorNeves, Nuno M.
dc.date.accessioned2020-04-17T11:19:56Z
dc.date.available2020-04-17T11:19:56Z
dc.date.issued2020
dc.description.abstractSea-derived materials have promising applications in the medical, pharmaceutical, and biotechnological fields. Fish roe, for example, is a highly nutritional product, presenting diverse beneficial effects on human health. Therefore, this work explored extracts of sardine (Sardina pilchardus) roe, due to the well-known health benefits of this fish, to produce novel and promising delivery systems. After morphological, histological, and histochemical characterizations of sardine roe, their lipids were extracted using two different approaches, namely, Bligh and Dyer (BD) and methyl-tert-butyl ether (MTBE) methods. Gas chromatography/mass spectrometry analyses demonstrated that lipid extracts contain several fatty acids, such as ω3 polyunsaturated fatty acids. The lipids, especially phospholipids, were used to produce multilamellar liposomes (MLVs). These delivery systems presented size heterogeneity, a negative surface charge, and the ability to control the release of the encapsulated anti-inflammatory drug, namely, celecoxib. Biological assays indicated that MLVs produced with MTBE lipidic extracts presented a better cytocompatibility than those obtained by the BD method. This can be further improved if the lipid extracts are processed by chemical extraction. Therefore, sardine roe-derived lipids can produce drug-delivery systems with the potential to be applied in the biomedical field.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationGuedes, M., Costa-Pinto, A. R., Gonçalves, V., Moreira-Silva, J., Tiritan, M., Reis, R. L., ..., Neves, N. M. (2020). Sardine roe as a source of lipids to produce liposomes. ACS Biomaterials Science & Engineering, 6(2), 1017-1029pt_PT
dc.identifier.doi10.1021/acsbiomaterials.9b01462pt_PT
dc.identifier.eid85079064182
dc.identifier.eissn2373-9878
dc.identifier.pmid33464869
dc.identifier.urihttp://hdl.handle.net/10400.14/30278
dc.identifier.wos000513086900022
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationFSE/POCH/PD/169/2013pt_PT
dc.relationIsolation and validation of fish roe derived-lipids and boactive agents for biomedical applications
dc.relationFETAL STEM CELLS EXPANDED WITH ANIMAL FREE COMPONENTS FOR MAXILO-FACIAL BONE REGENERATION USING PLATELET LYSATE LOADED CHITOSAN-POLYBUTYLENE SUCCINATE SCAFFOLDS
dc.relationPreclinical Validation of a TNF-Capturing Device as Therapeutics of Inflammatory Arthritic Diseases.
dc.subjectSardine roept_PT
dc.subjectBligh and Dyerpt_PT
dc.subjectMethyl-tert-butyl etherpt_PT
dc.subjectFatty acidspt_PT
dc.subjectLiposomespt_PT
dc.subjectCytocompatibilitypt_PT
dc.titleSardine roe as a source of lipids to produce liposomespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleIsolation and validation of fish roe derived-lipids and boactive agents for biomedical applications
oaire.awardTitleFETAL STEM CELLS EXPANDED WITH ANIMAL FREE COMPONENTS FOR MAXILO-FACIAL BONE REGENERATION USING PLATELET LYSATE LOADED CHITOSAN-POLYBUTYLENE SUCCINATE SCAFFOLDS
oaire.awardTitlePreclinical Validation of a TNF-Capturing Device as Therapeutics of Inflammatory Arthritic Diseases.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F113795%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F90332%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-BIO%2F4388%2F2014/PT
oaire.citation.endPage1029pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage1017pt_PT
oaire.citation.titleACS Biomaterials Science and Engineeringpt_PT
oaire.citation.volume6pt_PT
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamFARH
oaire.fundingStream3599-PPCDT
person.familyNameGuedes
person.familyNameCosta-Pinto
person.familyNameFerreira Gonçalves
person.familyNameTiritan
person.familyNameNeves
person.givenNameMarta
person.givenNameAna Rita
person.givenNameVirgínia Maria
person.givenNameMaria Elizabeth
person.givenNameNuno
person.identifier1310409
person.identifier166319
person.identifier.ciencia-id1313-66B7-2A1E
person.identifier.ciencia-idDB12-D51F-C2D7
person.identifier.ciencia-idD915-BFC0-FB3A
person.identifier.ciencia-id3013-6C92-AC79
person.identifier.orcid0000-0001-8486-4380
person.identifier.orcid0000-0002-4764-8539
person.identifier.orcid0000-0002-9151-516X
person.identifier.orcid0000-0003-3320-730X
person.identifier.orcid0000-0003-3041-0687
person.identifier.ridI-7483-2013
person.identifier.ridK-9492-2014
person.identifier.ridB-4685-2008
person.identifier.scopus-author-id24390737500
person.identifier.scopus-author-id23097687200
person.identifier.scopus-author-id6602890981
person.identifier.scopus-author-id7004622219
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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