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Histological and morphometrical evaluation of non-critical bone defects after treatment with biomaterial and bisphosphonates

2025-07-01Research article Open access
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dc.contributor.authorFernandes, Gustavo Vicentis Oliveira
dc.contributor.authorMartins, Bruno Gomes Dos Santos
dc.contributor.authorHeboyan, Artak
dc.contributor.authorCastilho, Rogerio Moraes
dc.contributor.authorFernandes, Juliana Campos Hasse
dc.date.accessioned2025-09-02T11:58:45Z
dc.date.available2025-09-02T11:58:45Z
dc.date.issued2025-07-01
dc.description.abstractBackground: The primary goal of this in vivo study was to ascertain if systemic bisphosphonates (BPs) positively affect bone repair in non-critical defects when assisted with a carbonated hydroxyapatite graft biomaterial (Biomat). Material and Methods: Thirty-six female rats were allocated into two control groups (blood clot [BC] and alloplastic biomaterial); two groups with zoledronate (third-generation BPs): Zol.BP and Zol.BP+Biomat; and two groups with clodronate (first-generation BPs): Clod.BP and the Clod.BP+Biomat. The experimental groups started the application of BP 60 days before surgery. Then, a 2 mm non-critical defect was performed in the rats’ femur and filled according to the group. All animals were euthanized 30 days after surgery, and the samples were collected for histological and histomorphometry analysis, respectively, for descriptive and quantitative analyses. Results: Zol.BP+Biomat had greater new bone formation, whereas clodronate presented high osteogenic potential, significantly increasing the observed levels of newly formed bone even in the absence of the biomaterial. Histomorphometrically, BC had 2% bone formation compared to the biomaterial group (5%). Zol.BP and Col.BP achieved bone formation of 6-fold (12%, p>0.05) and 9.5-fold (19%, p<0.05), respectively, when compared with BC. Zol.BP+Biomat group presented the highest value found for newly formed bone (24%), 12-fold more than BC (p<0.001) and 4.8-fold more than the biomaterial group (p<0.01). Conclusions: It is possible to conclude that the systemic use of BP positively affected non-critical bone defects when associated with biomaterials, mainly when the third generation of BPs was used in this association.eng
dc.identifier.citationFernandes, G. V. O., Martins, B. G. D. S., Heboyan, A., & Castilho, R. M. et al. (2025). Histological and morphometrical evaluation of non-critical bone defects after treatment with biomaterial and bisphosphonates. Medicina Oral Patologia Oral y Cirugia Bucal, 30(4), e491-e498. Article 27033. https://doi.org/10.4317/medoral.27033
dc.identifier.doi10.4317/medoral.27033
dc.identifier.eid105009380813
dc.identifier.issn1698-4447
dc.identifier.other2fb1bd87-53ff-4018-b01a-a2da57b11894
dc.identifier.pmcPMC12221150
dc.identifier.pmid40121683
dc.identifier.urihttp://hdl.handle.net/10400.14/54593
dc.identifier.wos001537878900004
dc.language.isoeng
dc.peerreviewedyes
dc.rights.uriN/A
dc.subjectAlloplastic biomaterial
dc.subjectBisphosphonates
dc.subjectBone defect
dc.subjectBone healing
dc.subjectIn vitro
dc.titleHistological and morphometrical evaluation of non-critical bone defects after treatment with biomaterial and bisphosphonateseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPagee498
oaire.citation.issue4
oaire.citation.startPagee491
oaire.citation.titleMedicina Oral Patologia Oral y Cirugia Bucal
oaire.citation.volume30
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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