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Evolution of Escherichia coli strains under competent or compromised adaptive immunity

2025-04-24Artigo de investigação Acesso aberto
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dc.contributor.authorAmeline, Camille
dc.contributor.authorSeixas, Elsa
dc.contributor.authorBarreto, Hugo C.
dc.contributor.authorFrazão, Nelson
dc.contributor.authorRodrigues, Miguel V.
dc.contributor.authorVentura, M. Rita
dc.contributor.authorLourenço, Marta
dc.contributor.authorGordo, Isabel
dc.date.accessioned2025-08-13T14:55:10Z
dc.date.available2025-08-13T14:55:10Z
dc.date.issued2025-04-24
dc.description.abstractEscherichia coli is a commensal of the intestine of most mammals, but also an important human pathogen. Within a healthy human its population structure is highly dynamic, where typically a dominant E. coli strain is accompanied by several low abundance satellite strains. However, the factors underlying E. coli strain dynamics and evolution within hosts are still poorly understood. Here, we colonised germ-free immune-competent (wild-type) or immune-compromised (Rag2KO) mice, with two phylogenetically distinct strains of E. coli, to determine if strain co-existence and within-strain evolution are shaped by the adaptive immune system. Irrespectively of the immune status of the mice one strain reaches a 100-fold larger abundance than the other. However, the abundance of the dominant strain is significantly higher in Rag2KO mice. Strains co-exist for thousands of generations and accumulate beneficial mutations in genes coding for different resource preferences. A higher rate of mutation accumulation in immune-compromised vs. immune-competent mice is observed and adaptative mutations specific to immune-competent mice are identified. Importantly, the presence of the adaptive immune system selects for mutations that increase stress resistance and the dynamics of such evolutionary events associates with the onset of an antibody response.eng
dc.identifier.citationAmeline, C., Seixas, E., Barreto, H. C., & Frazão, N. et al. (2025). Evolution of Escherichia coli strains under competent or compromised adaptive immunity. PLoS Pathogens, 21(4), Article e1012442. https://doi.org/10.1371/journal.ppat.1012442
dc.identifier.doi10.1371/journal.ppat.1012442
dc.identifier.eid105003439886
dc.identifier.issn1553-7366
dc.identifier.other229e03dd-edb0-49e6-990f-fc7571aa4d1f
dc.identifier.pmcPMC12021133
dc.identifier.pmid40273038
dc.identifier.urihttp://hdl.handle.net/10400.14/54552
dc.identifier.wos001475138200003
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleEvolution of Escherichia coli strains under competent or compromised adaptive immunityeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.titlePLoS Pathogens
oaire.citation.volume21
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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