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Gut as an alternative entry route for SARS-CoV-2: current evidence and uncertainties of productive enteric infection in COVID-19

2022-10Journal article Open access
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dc.contributor.authorClerbaux, Laure Alix
dc.contributor.authorMayasich, Sally A.
dc.contributor.authorMunoz Pineiro, Amalia
dc.contributor.authorSoares, Helena
dc.contributor.authorPetrillo, Mauro
dc.contributor.authorAlbertini, Maria Cristina
dc.contributor.authorLanthier, Nicolas
dc.contributor.authorGrenga, Lucia
dc.contributor.authorAmorim, Maria João
dc.date.accessioned2022-10-26T08:51:08Z
dc.date.available2022-10-26T08:51:08Z
dc.date.issued2022-10
dc.description.abstractThe gut has been proposed as a potential alternative entry route for SARS-CoV-2. This was mainly based on the high levels of SARS-CoV-2 receptor expressed in the gastrointestinal (GI) tract, the observations of GI disorders (such as diarrhea) in some COVID-19 patients and the detection of SARS-CoV-2 RNA in feces. However, the underlying mechanisms remain poorly understood. It has been proposed that SARS-CoV-2 can productively infect enterocytes, damaging the intestinal barrier and contributing to inflammatory response, which might lead to GI manifestations, including diarrhea. Here, we report a methodological approach to assess the evidence supporting the sequence of events driving SARS-CoV-2 enteric infection up to gut adverse outcomes. Exploring evidence permits to highlight knowledge gaps and current inconsistencies in the literature and to guide further research. Based on the current insights on SARS-CoV-2 intestinal infection and transmission, we then discuss the potential implication on clinical practice, including on long COVID. A better understanding of the GI implication in COVID-19 is still needed to improve disease management and could help identify innovative therapies or preventive actions targeting the GI tract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/jcm11195691pt_PT
dc.identifier.eid85138731529
dc.identifier.issn2077-0383
dc.identifier.pmcPMC9573230
dc.identifier.pmid36233559
dc.identifier.urihttp://hdl.handle.net/10400.14/39184
dc.identifier.wos000866849300001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectSARS-CoV-2 infectionpt_PT
dc.subjectEnteric infectionpt_PT
dc.subjectGastrointestinal disorderspt_PT
dc.subjectGut microbiotapt_PT
dc.titleGut as an alternative entry route for SARS-CoV-2: current evidence and uncertainties of productive enteric infection in COVID-19pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue19pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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