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Quantification of fluoroquinolones in wastewaters by liquid chromatography-tandem mass spectrometry

2020Journal article Restricted access
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dc.contributor.authorMaia, Alexandra S.
dc.contributor.authorPaíga, Paula
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorCastro, Paula M. L.
dc.contributor.authorTiritan, Maria Elizabeth
dc.date.accessioned2020-01-27T15:04:53Z
dc.date.available2020-01-27T15:04:53Z
dc.date.issued2020
dc.description.abstractAntibiotics are the most consumed therapeutic classes worldwide and are released to the environment in their original form as well as potentially active metabolites and/or degradation products. Consequences of the occurrence of these compounds in the environment are primarily related to bacterial resistance development. This work presents a validated analytical method based on solid phase extraction (SPE) using HLB cartridges, followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for quantification of seven different fluoroquinolone antibiotics, namely ciprofloxacin (CPF), enrofloxacin (ENR), lomefloxacin (LOM), norfloxacin (NOR), ofloxacin (OFL), prulifloxacin (PLF) and moxifloxacin (MOX) and its application to detect the target compounds in influents and effluents of wastewater treatment plants (WWTP). Linearity was established through calibration curves in solvent and matrix match using internal calibration method in the range of 50–1300 ng L−1 and all the fluoroquinolones showed good linear fit (r2 ≥ 0.991). Accuracy ranged between 80.3 and 92.9%, precision was comprised between 7.2 and 14.6%, and 10.7 and 18.1% for intra- and inter-batch determinations, respectively. Method detection and quantification limits ranged from 6.7 to 59.0 ng L−1 and 22.3–196.6 ng L−1, respectively. Influents and effluents of fifteen WWTPs of North of Portugal were analyzed. OFL was the fluoroquinolone found at the highest concentration, up to 4587.0 ng L−1 and 987.9 ng L−1, in influent and effluent, respectively. NOR and PLF were not detected.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMaia, A. S., Paíga, P., Delerue-Matos, C., Castro, P. M., Tiritan, M. E. (2020). Quantification of fluoroquinolones in wastewaters by liquid chromatography-tandem mass spectrometry. Environmental Pollution, 259:113927pt_PT
dc.identifier.doi10.1016/j.envpol.2020.113927pt_PT
dc.identifier.eid85077741448
dc.identifier.issn0269-7491
dc.identifier.pmid32023795
dc.identifier.urihttp://hdl.handle.net/10400.14/29352
dc.identifier.wos000528534600002
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPEst/FCOMP/01/0124/FEDER/022718pt_PT
dc.relationFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.titleQuantification of fluoroquinolones in wastewaters by liquid chromatography-tandem mass spectrometrypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEBB-EBI%2F111699%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FSAU%2FUI4040%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2019/PT
oaire.citation.titleEnvironmental Pollutionpt_PT
oaire.citation.volume259pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMaia
person.familyNameCastro
person.familyNameTiritan
person.givenNameAlexandra S.
person.givenNamePaula
person.givenNameMaria Elizabeth
person.identifier2013444
person.identifier1310409
person.identifier.ciencia-id6A15-F0A3-AEF2
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.ciencia-idD915-BFC0-FB3A
person.identifier.orcid0000-0002-4167-383X
person.identifier.orcid0000-0001-8841-6606
person.identifier.orcid0000-0003-3320-730X
person.identifier.ridM-8241-2013
person.identifier.ridK-9492-2014
person.identifier.scopus-author-id55332349300
person.identifier.scopus-author-id7102781782
person.identifier.scopus-author-id6602890981
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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