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Occurrence of chiral bioactive compounds in the aquatic environment: a review

dc.contributor.authorRibeiro, Cláudia
dc.contributor.authorRibeiro, Ana Rita
dc.contributor.authorMaia, Alexandra S.
dc.contributor.authorTiritan, Maria Elizabeth
dc.date.accessioned2018-11-06T10:53:17Z
dc.date.available2018-11-06T10:53:17Z
dc.date.issued2017
dc.description.abstractIn recent decades, the presence of micropollutants in the environment has been extensively studied due to their high frequency of occurrence, persistence and possible adverse effects to exposed organisms. Concerning chiral micropollutants in the environment, enantiomers are frequently ignored and enantiomeric composition often neglected. However, enantioselective toxicity is well recognized, highlighting the need to include enantioselectivity in environmental risk assessment. Additionally, the information about enantiomeric fraction (EF) is crucial since it gives insights about: (i) environmental fate (i.e., occurrence, distribution, removal processes and (bio)degradation); (ii) illicit discharges; (iii) consumption pattern (e.g., illicit drugs, pharmaceuticals used as recreational drugs, illicit use of pesticides); and (iv) enantioselective toxicological effects. Thus, the purpose of this paper is to provide a comprehensive review about the enantioselective occurrence of chiral bioactive compounds in aquatic environmental matrices. These include pharmaceuticals, illicit drugs, pesticides, polychlorinated biphenyls (PCBs) and polycyclic musks (PCMs). Most frequently analytical methods used for separation of enantiomers were liquid chromatography and gas chromatography methodologies using both indirect (enantiomerically pure derivatizing reagents) and direct methods (chiral stationary phases). The occurrence of these chiral micropollutants in the environment is reviewed and future challenges are outlined.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro, C., Ribeiro, A.R., Maia, A.S., Tiritan, M.E. (2017). Occurrence of chiral bioactive compounds in the aquatic environment: A review. Symmetry, 9(10), art. n.º 215pt_PT
dc.identifier.doi10.3390/sym9100215pt_PT
dc.identifier.eid85031409340
dc.identifier.issn2073-8994
dc.identifier.urihttp://hdl.handle.net/10400.14/25989
dc.identifier.wos000414911000018
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationDevelopment of a miniaturized sample preparation prototype for identification and quantification of trace pharmaceuticals in tap waters
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChiral drugspt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectIllicit drugspt_PT
dc.subjectPesticidespt_PT
dc.subjectChiral chromatographypt_PT
dc.subjectEnvironmentpt_PT
dc.titleOccurrence of chiral bioactive compounds in the aquatic environment: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a miniaturized sample preparation prototype for identification and quantification of trace pharmaceuticals in tap waters
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04423%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F86939%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F101703%2F2014/PT
oaire.citation.issue10
oaire.citation.titleSymmetrypt_PT
oaire.citation.volume9
oaire.fundingStream5876
oaire.fundingStreamSFRH
oaire.fundingStreamFARH
person.familyNameRibeiro
person.familyNameRibeiro
person.familyNameMaia
person.familyNameTiritan
person.givenNameClaudia
person.givenNameAna Rita Lado
person.givenNameAlexandra S.
person.givenNameMaria Elizabeth
person.identifier903786
person.identifier1310409
person.identifier.ciencia-id9D17-0C17-2703
person.identifier.ciencia-id421D-DC6E-F6E3
person.identifier.ciencia-id6A15-F0A3-AEF2
person.identifier.ciencia-idD915-BFC0-FB3A
person.identifier.orcid0000-0001-7245-4552
person.identifier.orcid0000-0002-4445-5379
person.identifier.orcid0000-0002-4167-383X
person.identifier.orcid0000-0003-3320-730X
person.identifier.ridK-9492-2014
person.identifier.scopus-author-id56835095200
person.identifier.scopus-author-id57207918943
person.identifier.scopus-author-id55332349300
person.identifier.scopus-author-id6602890981
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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