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Effects of extracts of selected medicinal plants upon hepatic oxidative stress

2010-03Journal article Restricted access
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dc.contributor.authorGião, M.S.
dc.contributor.authorPestana, D.
dc.contributor.authorFaria, A.
dc.contributor.authorGuimarães, J.T.
dc.contributor.authorPintado, M.E.
dc.contributor.authorCalhau, C.
dc.contributor.authorAzevedo, I.
dc.contributor.authorMalcata, F.X.
dc.date.accessioned2010-10-06T10:13:45Z
dc.date.available2010-10-06T10:13:45Z
dc.date.issued2010-03
dc.description.abstractAqueous extracts of a few medicinal plants traditionally used in Portugal have been assayed for their effects upon hepatic oxidative stress in mice. Previous in vitro studies had allowed characterization of agrimony, sage, savory, and raspberry in terms of overall antioxidant capacity and phenolic content. In the present study, the antioxidant effect and safety of these four plants were evaluated in vivo. For this purpose, mice ingested extracts in aqueous form (or water, used as the control) for 4 weeks; damage to lipids, proteins, and DNA was evaluated by oxidative cell biomarkers by the end of that period. Levels of hepatic glutathione and activities of enzymes involved in metabolism thereof were also determined. Finally, catalase and superoxide dismutase (SOD) activities were quantified, as these enzymes play a crucial role in antioxidant defense. When compared with the control, both raspberry and savory produced significant lipid protection; however, protein damage was significantly lower only in raspberry-treated animals. On the other hand, DNA damage was prevented only by savory. All plants led to a decrease in catalase activity, whereas all but sage also produced a decrease in SOD activity. With regard to glutathione levels and activities of enzymes involved in its metabolism, the aforementioned extracts exhibited different effects. In general, raspberry appeared to be the most promising extract, followed by savory, sage, and agrimony, sorted by decreasing performance in protection; the latter was even slightly toxic. Hence, the plants tested possess compounds with interesting biological activities that may support eventual inclusion in food or feed as functional additives.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1089/jmf.2008.0323
dc.identifier.eissn1557-7600
dc.identifier.issn1096-620X
dc.identifier.pmid20136446
dc.identifier.urihttp://hdl.handle.net/10400.14/2661
dc.identifier.wos000274329600018
dc.identifier.wos76649088665
dc.language.isoengpor
dc.publisherMary Ann Liebert, Inc.por
dc.relation13-05-04-FDR-00020
dc.relationANTIOXIDANTS IN HERBAL TEAS AS FUNCTIONAL INGREDIENTS: EXTRACTION, CHARACTERIZATION, BIOAVAILABILITY, ACTIVITY AND APPLICATIONS
dc.subjectDynamic convective dryingpor
dc.subjectWater diffusivitypor
dc.subjectGrapespor
dc.subjectNumerical modellingpor
dc.titleEffects of extracts of selected medicinal plants upon hepatic oxidative stresspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleANTIOXIDANTS IN HERBAL TEAS AS FUNCTIONAL INGREDIENTS: EXTRACTION, CHARACTERIZATION, BIOAVAILABILITY, ACTIVITY AND APPLICATIONS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F19601%2F2004/PT
oaire.citation.endPage136
oaire.citation.issue1
oaire.citation.startPage131
oaire.citation.titleJournal of Medicinal Food
oaire.citation.volume13
person.familyNamePestana
person.familyNameFaria
person.familyNameGuimarães
person.familyNamePintado
person.familyNameCalhau
person.familyNameMalcata
person.givenNameDiogo
person.givenNameAna
person.givenNameJoão Tiago
person.givenNameMaria Manuela
person.givenNameConceição
person.givenNameFrancisco
person.identifier456608
person.identifier.ciencia-idA016-7E69-E3AD
person.identifier.ciencia-idA517-225B-FB03
person.identifier.ciencia-idE817-6AD8-E6C3
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.ciencia-id2110-0420-1717
person.identifier.ciencia-id1B13-38A5-35F5
person.identifier.orcid0000-0001-6332-7914
person.identifier.orcid0000-0002-5165-9513
person.identifier.orcid0000-0003-4836-6311
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0001-9567-3379
person.identifier.orcid0000-0003-3073-1659
person.identifier.ridT-3079-2017
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id23568608000
person.identifier.scopus-author-id35232999100
person.identifier.scopus-author-id7102733078
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id6701578877
person.identifier.scopus-author-id7102542478
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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