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Prenatal ultrasound and postmortem histologic evaluation of tooth germs: an observational, transversal study

2015-05-12Artigo científico Acesso aberto
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dc.contributor.authorSeabra, Mariana
dc.contributor.authorFelino, António
dc.contributor.authorNogueira, Rosete
dc.contributor.authorValente, Francisco
dc.contributor.authorBraga, Cristina A.
dc.contributor.authorVaz, Paula
dc.date.accessioned2021-06-24T13:58:38Z
dc.date.available2021-06-24T13:58:38Z
dc.date.issued2015-05-12
dc.description.abstractIntroduction: Hypodontia is the most frequent developmental anomaly of the orofacial complex, and its detection in prenatal ultrasound may indicate the presence of congenital malformations, genetic syndromes and chromosomal abnormalities. Methods: Observational, descriptive, transversal study. The study protocol followed the ethical principles outlined by the Helsinki Declaration and was approved by the Ethics Committee of the School of Dental Medicine, University of Porto (FMDUP, Porto, Portugal) and of the Centro Hospitalar de Vila Nova de Gaia/Espinho (CHVNG/EPE, Porto, Portugal) as well as by the CGC Genetics Embryofetal Pathology Laboratory. Eighty-five fetuses examined by prenatal ultrasound screening from May 2011 to August 2012 had an indication for autopsy following spontaneous fetal death or medical termination of pregnancy. Of the 85 fetuses, 37 (43.5%) were randomly selected for tooth germ evaluation by routine histopathological analysis. Fetuses who were up to 30 weeks of gestation, and whose histological pieces were not representative of all maxillary tooth germs was excluded. Twenty four fetus between the 13th and 30th weeks of gestation fulfilled the parameters to autopsy. Results: Twenty four fetuses were submitted to histological evaluation and were determined the exact number, morphology, and mineralization of their tooth germs. All tooth germs were identifiable with ultrasonography as early as the 13th week of gestation. Of the fetuses autopsied, 41.7% had hypodontia (29.1% maxillary hypodontia and 20.9% mandibular hypodontia). Conclusions: This results indicate that prenatal ultrasound is a reliable method for detecting of hypodontia an early gestational ages. Further studies with larger samples are needed to confirm these results.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1186/s13005-015-0075-8pt_PT
dc.identifier.eid84929460547
dc.identifier.issn1746-160X
dc.identifier.pmid25962445
dc.identifier.urihttp://hdl.handle.net/10400.14/33935
dc.identifier.wos000354928100001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDiagnosispt_PT
dc.subjectHistologypt_PT
dc.subjectPrenatalpt_PT
dc.subjectTooth budspt_PT
dc.subjectTooth germpt_PT
dc.subjectUltrasoundpt_PT
dc.titlePrenatal ultrasound and postmortem histologic evaluation of tooth germs: an observational, transversal studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleHead and Face Medicinept_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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