Publicação
Average pain over time, but not current pain, is associated with salivary secretory immunoglobulin a in chronic back pain: a cross-sectional study
| dc.contributor.author | Shani, Adi | |
| dc.contributor.author | Granot, Michal | |
| dc.contributor.author | Palzur, Eilam | |
| dc.contributor.author | Agostinho, Mariana | |
| dc.contributor.author | Treister, Roi | |
| dc.contributor.author | Rahamimov, Nimrod | |
| dc.date.accessioned | 2026-09-04T16:10:23Z | |
| dc.date.available | 2026-09-04T16:10:23Z | |
| dc.date.issued | 2026-08-01 | |
| dc.description.abstract | Chronic pain is accompanied by widespread physiological dysregulation, yet the mucosal immune system has received little attention. Salivary secretory-immunoglobulin-A (S-IgA) is a non-invasive biomarker of mucosal immunity modulated by sustained stress and autonomic activity. This cross-sectional secondary analysis examined whether pain intensity in chronic back pain is associated with salivary S-IgA in 57 adults enrolled in a parent interventional study (NCT05994118). Pain was assessed on a computerized visual analogue scale (CoVAS, 0-100) at the laboratory visit (current pain and 24-hour average) and via a twice-daily electronic CoVAS diary (1-week, 2-week, and 14-day averages). Two saliva samples collected ∼90 minutes apart were assayed by ELISA, and baseline heart rate variability (HRV) was recorded. Spearman correlations were computed with and without partial adjustment for age, sex, and BMI; Benjamini-Hochberg correction was applied to the ten primary pain × S-IgA tests. Average 24-hour pain was negatively correlated with both S-IgA samples (ρ ≈ -.45 for both, p < .001); the 1-week (ρ ≈ -.34 to -.35, p ≤ .009) and 14-day averages (ρ ≈ -.38 for both, p = .004) showed similar associations. All average-pain associations survived FDR correction and partial adjustment. Current pain was not significantly associated with S-IgA. Baseline high-frequency HRV power was positively associated with S-IgA1 (ρ = .29, p = .033) but not S-IgA2. Sustained pain experience, rather than current pain, appears to track salivary mucosal immune function in chronic back pain. However, these hypothesis-generating findings may reflect unmeasured stress- or mood-related confounding, not a pain-specific effect. | eng |
| dc.identifier.doi | 10.1177/17448069261483479 | |
| dc.identifier.eid | 105048087853 | |
| dc.identifier.other | 511d9c19-ab19-4f61-8970-8e182bd9a958 | |
| dc.identifier.pmid | 42635010 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/59261 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | SAGE Publications Inc. | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | |
| dc.subject | Allostatic load | eng |
| dc.subject | Chronic back pain | eng |
| dc.subject | Heart rate variability | eng |
| dc.subject | Mucosal immunity | eng |
| dc.subject | S-IgA | eng |
| dc.subject | Secretory immunoglobulin A | eng |
| dc.title | Average pain over time, but not current pain, is associated with salivary secretory immunoglobulin a in chronic back pain: a cross-sectional study | |
| dc.type | research article | |
| dspace.entity.type | Publication | |
| oaire.citation.volume | 22 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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