Repository logo
 
Publication

Novel and revisited approaches in nanoparticle systems for buccal drug delivery

2020Journal article Open access
Simple item page
dc.contributor.authorMacedo, Ana S.
dc.contributor.authorCastro, Pedro M.
dc.contributor.authorRoque, Luís
dc.contributor.authorThomé, Natália G.
dc.contributor.authorReis, Catarina P.
dc.contributor.authorPintado, Maria Manuela
dc.contributor.authorFonte, Pedro
dc.date.accessioned2020-01-14T11:18:20Z
dc.date.available2021-04-10T00:30:11Z
dc.date.issued2020
dc.description.abstractThe buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastrointestinal tract. However, the drug concentration absorbed in the buccal mucosa is often low to obtain an acceptable therapeutic effect, mainly due to the saliva turnover, tongue and masticatory movements, phonation, enzymatic degradation and lack of epithelium permeation. Therefore, the encapsulation of drugs into nanoparticles is an important strategy to avoid such problems and improve their buccal delivery. Different materials from lipids to natural or synthetic polymers and others have been used to protect and deliver drugs in a sustained, controlled or targeted manner, and enhance their uptake through the buccal mucosa improving their bioavailability and therapeutic outcome. Overall, the main aim of this review is to perform an overview about the nanotechnological approaches developed so far to improve the buccal delivery of drugs. Herein, several types of nanoparticles and delivery strategies are addressed, and a special focus on pipeline products is also given.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationMacedo, A. S., Castro, P. M., Roque, L., Thomé, N. G., Reis, C. P., Pintado, M. E., Fonte, P. (2020). Novel and revisited approaches in nanoparticle systems for buccal drug delivery. Journal of Controlled Releasept_PT
dc.identifier.doi10.1016/j.jconrel.2020.01.006pt_PT
dc.identifier.eid85078133048
dc.identifier.issn0168-3659
dc.identifier.pmid31917295
dc.identifier.urihttp://hdl.handle.net/10400.14/29233
dc.identifier.wos000522794800011
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPOCI/01/0145/FEDER/032610pt_PT
dc.relationPTDC/MEC/DER/32610/2017pt_PT
dc.subjectBuccal deliverypt_PT
dc.subjectNanoparticlept_PT
dc.subjectPolymerpt_PT
dc.subjectLipidpt_PT
dc.subjectDrug deliverypt_PT
dc.subjectPermeation enhancerpt_PT
dc.titleNovel and revisited approaches in nanoparticle systems for buccal drug deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Controlled Releasept_PT
person.familyNameMiranda de Castro
person.familyNamePintado
person.givenNamePedro João
person.givenNameMaria Manuela
person.identifier456608
person.identifier.ciencia-id5112-6B99-DC1F
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0001-7164-8005
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id57201808340
person.identifier.scopus-author-id7004483898
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication99909754-7408-4e67-8f02-9cdb3c5a88d4
relation.isAuthorOfPublicationba387c7d-27c9-4016-895c-b35597e91ebc
relation.isAuthorOfPublication.latestForDiscoveryba387c7d-27c9-4016-895c-b35597e91ebc

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
19707584.pdf
Size:
4.71 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.44 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CBQF - Contribuições em Revistas Científicas / Contribution to Journals