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Magnitude and temporal variations of socioeconomic inequalities in the quality of life after early breast cancer: results from the multicentric French CANTO Cohort

2024-08-20Journal article Open access
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dc.contributor.authorSandoval, José Luis
dc.contributor.authorFranzoi, Maria Alice
dc.contributor.authorDi Meglio, Antonio
dc.contributor.authorFerreira, Arlindo R.
dc.contributor.authorViansone, Alessandro
dc.contributor.authorAndré, Fabrice
dc.contributor.authorMartin, Anne Laure
dc.contributor.authorEverhard, Sibille
dc.contributor.authorJouannaud, Christelle
dc.contributor.authorFournier, Marion
dc.contributor.authorRouanet, Philippe
dc.contributor.authorVanlemmens, Laurence
dc.contributor.authorDhaini-Merimeche, Asma
dc.contributor.authorSauterey, Baptiste
dc.contributor.authorCottu, Paul
dc.contributor.authorLevy, Christelle
dc.contributor.authorStringhini, Silvia
dc.contributor.authorGuessous, Idris
dc.contributor.authorVaz-Luis, Ines
dc.contributor.authorMenvielle, Gwenn
dc.date.accessioned2024-09-18T15:28:10Z
dc.date.available2024-09-18T15:28:10Z
dc.date.issued2024-08-20
dc.description.abstractPURPOSE: Socioeconomic status (SES) influences the survival outcomes of patients with early breast cancer (EBC). However, limited research investigates social inequalities in their quality of life (QoL). This study examines the socioeconomic inequalities in QoL after an EBC diagnosis and their time trends. PATIENTS AND METHODS: We used data from the French prospective multicentric CANTO cohort (ClinicalTrials.gov identifier: NCT01993498), including women with EBC enrolled between 2012 and 2018. QoL was assessed using the European Organisation for Research and Treatment of Cancer QoL Core 30 questionnaire (QLQ-C30). summary score at diagnosis and 1 and 2 years postdiagnosis. We considered three indicators of SES separately: self-reported financial difficulties, household income, and educational level. We first analyzed the trajectories of the QLQ-C30 summary score by SES group. Then, social inequalities in QLQ-C30 summary score and their time trends were quantified using the regression-based slope index of inequality (SII), representing the absolute change in the outcome along socioeconomic gradient extremes. The analyses were adjusted for age at diagnosis, Charlson Comorbidity Index, disease stage, and type of local and systemic treatment. RESULTS: Among the 5,915 included patients with data on QoL at diagnosis and at the 2-year follow-up, social inequalities in QLQ-C30 summary score at baseline were statistically significant for all SES indicators (SIIfinancial difficulties = -7.6 [-8.9; -6.2], SIIincome = -4.0 [-5.2; -2.8]), SIIeducation = -1.9 [-3.1; -0.7]). These inequalities significantly increased (interaction P <.05) in year 1 and year 2 postdiagnosis, irrespective of prediagnosis health, tumor characteristics, and treatment. Similar results were observed in subgroups defined by menopausal status and type of adjuvant systemic treatment. CONCLUSION: The magnitude of preexisting inequalities in QoL increased over time after EBC diagnosis, emphasizing the importance of considering social determinants of health during comprehensive cancer care planning.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1200/JCO.23.02099pt_PT
dc.identifier.eid85201437939
dc.identifier.issn0732-183X
dc.identifier.pmcPMC11328924
dc.identifier.pmid38889372
dc.identifier.urihttp://hdl.handle.net/10400.14/46595
dc.identifier.wos001291914000007
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.titleMagnitude and temporal variations of socioeconomic inequalities in the quality of life after early breast cancer: results from the multicentric French CANTO Cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue24pt_PT
oaire.citation.titleJournal of Clinical Oncologypt_PT
oaire.citation.volume42pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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