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Association of prodromal Parkinson's disease-like features in long COVID with dream-enactment behaviours

2026-05-31Artigo de investigação Acesso aberto
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dc.contributor.authorGong, Siyi
dc.contributor.authorLiu, Yaping
dc.contributor.authorHuang, Bei
dc.contributor.authorChan, Ngan Yin
dc.contributor.authorPartinen, Eemil
dc.contributor.authorBenedict, Christian
dc.contributor.authorBjorvatn, Bjorn
dc.contributor.authorMerikanto, Ilona
dc.contributor.authorGennaro, Luigi De
dc.contributor.authorDauvilliers, Yves
dc.contributor.authorHolzinger, Brigitte
dc.contributor.authorYordanova, Juliana
dc.contributor.authorKorman, Maria
dc.contributor.authorReis, Catia
dc.contributor.authorLandtblom, Anne-Marie
dc.contributor.authorMota-Rolim, Sergio
dc.contributor.authorNadorff, Michael R.
dc.contributor.authorChung, Frances
dc.contributor.authorInoue, Yuichi
dc.contributor.authorHrubos-Strom, Harald
dc.contributor.authorMatsui, Kentaro
dc.contributor.authorBolstad, Courtney J.
dc.contributor.authorXue, Pei
dc.contributor.authorEspie, Colin A.
dc.contributor.authorMorin, Charles M.
dc.contributor.authorPenzel, Thomas
dc.contributor.authorPlazzi, Giuseppe
dc.contributor.authorPartinen, Markku
dc.contributor.authorWing, Yun Kwok
dc.date.accessioned2026-06-11T15:59:32Z
dc.date.available2026-06-11T15:59:32Z
dc.date.issued2026-05-31
dc.description.abstractEmerging evidence links COVID-19 to the predisposition of Parkinson's disease (PD). However, the relationship between long COVID and prodromal PD-like features remains unclear, particularly in long COVID participants with dream-enactment behaviours (DEBs) that may be suggestive of possible REM sleep behaviour disorder. This study aimed to quantify the burden of prodromal PD-like features in long COVID. This online survey (May–Nov 2021) across 16 countries/regions included 11,261 participants. Data on demographics, COVID-19 diagnosis, long COVID symptoms, sleep features and other typical prodromal PD-like features were collected. The likelihood ratio (LR) of prodromal PD was calculated as a proxy for each participant's overall burden of prodromal PD-like features, based on the 2019 Movement Disorder Society research criteria. Participants with long COVID (n=1155) exhibited more symptoms suggestive of prodromal PD-like features, including DEBs, olfactory dysfunctions, constipation, excessive daytime sleepiness, postural dizziness, depression with/without anxiety, urinary dysfunctions, cognitive impairment and a higher LR of prodromal PD when compared to non-COVID-19 participants and COVID-19 recoverees. Long COVID was associated with a 73% higher burden of potential prodromal PD-like features (adjusted odds ratio [aOR]=1.73, 95% confidence interval [CI]=1.57–1.90). Among those with long COVID, emergence or exacerbation of post-infection DEBs further increased this burden by 38% (aOR=1.38, 95% CI=1.19–1.60). Our study suggested that long COVID is associated with an increased burden of prodromal PD-like features, which appears to be further enhanced with DEBs.eng
dc.identifier.doi10.1111/jsr.70371
dc.identifier.eid105040624872
dc.identifier.other969724c8-36a9-4292-ba65-8af9ce4fac21
dc.identifier.pmid42219699
dc.identifier.urihttp://hdl.handle.net/10400.14/58085
dc.identifier.wos001781068700001
dc.language.isoeng
dc.peerreviewedyes
dc.publisherJohn Wiley and Sons Inc.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCoronavirus disease 2019 (COVID-19)eng
dc.subjectDream enactment behaviours (DEBs)eng
dc.subjectInternational COVID-19 sleep study (ICOSS)eng
dc.subjectLong COVIDeng
dc.subjectNeurodegenerationeng
dc.subjectProdromal Parkinson's disease (PD)eng
dc.titleAssociation of prodromal Parkinson's disease-like features in long COVID with dream-enactment behaviours
dc.typeresearch article
dspace.entity.typePublication
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa

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