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Bioactive hydrolysates from chlorella vulgaris: optimal process and bioactive properties

2022-04-13Journal article Open access
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dc.contributor.authorCunha, Sara A.
dc.contributor.authorCoscueta, Ezequiel R.
dc.contributor.authorNova, Paulo
dc.contributor.authorSilva, Joana Laranjeira
dc.contributor.authorPintado, Maria Manuela
dc.date.accessioned2022-04-19T17:50:11Z
dc.date.available2022-04-19T17:50:11Z
dc.date.issued2022-04-13
dc.description.abstractMicroalgae have been described as a source of bioactive compounds, such as peptides. Microalgae are easy to produce, making them a sustainable resource for extracting active ingredients for industrial applications. Several microalgae species have interesting protein content, such as Chlorella vulgaris with around 52.2% of protein, making it promising for peptide hydrolysate production. Therefore, this work focused on the production of water-soluble hydrolysates rich in proteins/peptides from the microalgae C. vulgaris and studied bioactive properties. For that, a design of experiments (DOE) was performed to establish the optimal conditions to produce hydrolysates with higher levels of protein, as well as antioxidant and antihypertensive properties. Four experimental factors were considered (cellulase percentage, protease percentage, hydrolysis temperature, and hydrolysis duration) for three responses (protein content, antioxidant activity, and antihypertensive activity). The optimal conditions determined by the DOE allowed producing a scaled-up hydrolysate with 45% protein, with antioxidant activity, measured by oxygen radical absorbance capacity assay, of 1035 µmol TE/g protein, IC50 for angiotensin-converting enzyme inhibition activity of 286 µg protein/mL, and α-glucosidase inhibition of 31% (30 mg hydrolysate/mL). The obtained hydrolysates can be used as functional ingredients for food and nutraceuticals due to their antioxidant, antihypertensive, and antidiabetic potential. Moreover, the antioxidant potential of the extracts may be relevant for the cosmetic industry, especially in antiaging formulations.</jats:p>pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules27082505pt_PT
dc.identifier.eid85129073510
dc.identifier.issn1420-3049
dc.identifier.pmcPMC9026812
dc.identifier.pmid35458702
dc.identifier.urihttp://hdl.handle.net/10400.14/37333
dc.identifier.wos000785140100001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMultifunctional natural derived peptide extracts for skin care
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidantpt_PT
dc.subjectAntihypertensivept_PT
dc.subjectEnzymatic hydrolysispt_PT
dc.subjectAlternative protein sourcept_PT
dc.subjectBioactive peptidespt_PT
dc.subjectFunctional foodpt_PT
dc.subjectMarine hydrolysatespt_PT
dc.subjectSustainabilitypt_PT
dc.titleBioactive hydrolysates from chlorella vulgaris: optimal process and bioactive propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMultifunctional natural derived peptide extracts for skin care
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F144155%2F2019/PT
oaire.citation.issue8
oaire.citation.titleMoleculespt_PT
oaire.citation.volume27pt_PT
oaire.fundingStreamPOR_NORTE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication84ef0bdf-69e8-4002-a926-974723d66e07
relation.isProjectOfPublication.latestForDiscovery84ef0bdf-69e8-4002-a926-974723d66e07

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