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PVP formulations of bis-cyclometalated iridium(III) complexes bearing β-modified porphyrin ligands: characterization and photodynamic action on bladder cancer cells

2025-04-01Artigo de investigação Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMoura, Nuno M. M.
dc.contributor.authorReis, Melani J. A.
dc.contributor.authorLodeiro, Carlos
dc.contributor.authorNeves, M. Graça P. M. S.
dc.contributor.authorCavaleiro, José A. S.
dc.contributor.authorRibeiro, Carlos F.
dc.contributor.authorFernandes, Rosa
dc.contributor.authorGomes, Ana T. P. C.
dc.date.accessioned2025-08-13T13:41:06Z
dc.date.available2025-08-13T13:41:06Z
dc.date.issued2025-04-01
dc.description.abstractCancer stands as the second leading global cause of death, following heart disease. Considering the severe side effects revealed by some chemotherapeutics for tumor treatment and anticancer therapies, the scientific community is actively exploring more effective alternatives. Photodynamic Therapy (PDT) mediated by porphyrin-based photosensitizers (PS) has emerged as an attractive alternative to more conventional therapies. In this study, we incorporated bis-cyclometalated iridium(III) complexes featuring porphyrin-arylbipyridine ligands into poly(vinylpyrrolidone) (PVP) micelle. This integration resulted in photostable PVP-PS formulations with a remarkable capability to generate singlet oxygen. These formulations were also efficiently internalized by HT-1379 cells and due to these features, their photodynamic action against human bladder cancer cells (HT-1376 cell line) was assessed. All the formulations demonstrated high photodynamic activity, with PVP-2 and PVP-3 proving to be the most promising PS, as evidenced by their lower IC50PDT values. It was also demonstrated that all PVP-based formulations provide a safe and effective approach for photodynamic therapy (PDT) in bladder cancer, as no cytotoxic effects were observed in Vero cells.eng
dc.identifier.citationMoura, N. M. M., Reis, M. J. A., Lodeiro, C., & Neves, M. G. P. M. S. et al. (2025). PVP formulations of bis-cyclometalated iridium(III) complexes bearing β-modified porphyrin ligands: characterization and photodynamic action on bladder cancer cells. Dyes and Pigments, 235, Article 112580. https://doi.org/10.1016/j.dyepig.2024.112580
dc.identifier.doi10.1016/j.dyepig.2024.112580
dc.identifier.eid85212537758
dc.identifier.issn0143-7208
dc.identifier.othera311dda0-7c46-4edd-bec0-3ed8d04aabbd
dc.identifier.urihttp://hdl.handle.net/10400.14/54533
dc.identifier.wos001392009800001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCancer
dc.subjectIridium complexes
dc.subjectPhotodynamic therapy
dc.subjectPhotosensitizer
dc.subjectPorphyrins
dc.titlePVP formulations of bis-cyclometalated iridium(III) complexes bearing β-modified porphyrin ligands: characterization and photodynamic action on bladder cancer cellseng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.titleDyes and Pigments
oaire.citation.volume235
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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