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Cathodic voltammetric detection of diltiazem at a bismuth film electrode: application to human urine and pharmaceuticals

2014-05Journal article Open access
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dc.contributor.authorCatarino, Rita I. L.
dc.contributor.authorLeal, M. Fernanda C.
dc.contributor.authorPimenta, Adriana M.
dc.contributor.authorSouto, M. Renata S.
dc.contributor.authorLopes, Joana R. T.
dc.date.accessioned2021-09-08T16:43:47Z
dc.date.available2021-09-08T16:43:47Z
dc.date.issued2014-05
dc.description.abstractIn this work it was developed a novel application of bismuth film electrodes (BiFEs) for the determination of the antihypertensive and coronary vasodilator diltiazem by square wave cathodic voltammetry. The bismuth film was deposited ex situ on a glassy carbon electrode for 90 s at -1.4 V vs. Ag/AgCl, from an acetate buffer (pH 4.5; 0.10 mol L-1) containing 5 or 30 mg L -1 Bi. Diltiazem analytical signal was obtained in phosphate buffer (pH 7.4; 0.25 mol L-1) where reduction takes place at -1.5 V vs. Ag/AgCl. The proposed methodology was applied to the quantification of diltiazem in pharmaceutical samples (dynamic linear range comprised between 90 and 900 μg L-1) and in human urine (dynamic linear range comprised between 45 and 270 μg L-1, and detection limit of 12 μg L -1).pt_PT
dc.description.abstractNeste trabalho foi desenvolvida uma nova metodologia de voltametria catódica de onda quadrada com elétrodo de filme de bismuto (BiFE) para a determinação de um anti-hipertensivo e vasodilatador coronário – o diltiazem. O filme de bismuto foi depositado ex situ na superfície de um elétrodo de carbono vítreo durante 90 s a um potencial de –1,4 V vs. Ag/AgCl, usando uma solução de tampão acetato (pH 4,5; 0,10 mol L-1) contendo 5 ou 30 mg L-1 de Bi. O sinal analítico do diltiazem foi obtido numa solução de tampão fostato (pH 7,4; 0,25 mol L-1) onde se verificou que a redução ocorria a –1,5 V vs. Ag/AgCl. A metodologia proposta foi aplicada à quantificação de diltiazem em formulações farmacêuticas (faixa linear de resposta compreendida entre 90 e 900 µg L-1) e em amostras de urina (faixa linear de resposta compreendida entre 45 e 270 µg L-1, e limite de deteção de 12 µg L-1).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.5935/0103-5053.20140067pt_PT
dc.identifier.eid84902346566
dc.identifier.issn0103-5053
dc.identifier.urihttp://hdl.handle.net/10400.14/34698
dc.identifier.wos000335817400020
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectBismuth film electrodept_PT
dc.subjectDiltiazempt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectVoltammetrypt_PT
dc.titleCathodic voltammetric detection of diltiazem at a bismuth film electrode: application to human urine and pharmaceuticalspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage968pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage961pt_PT
oaire.citation.titleJournal of the Brazilian Chemical Societypt_PT
oaire.citation.volume25pt_PT
person.familyNameCatarino
person.familyNameLeal
person.familyNamePimenta
person.familyNameSouto
person.givenNameRita
person.givenNameFernanda
person.givenNameAdriana
person.givenNameRenata
person.identifier.ciencia-idB517-2F1F-F2E4
person.identifier.ciencia-id5916-B87F-2482
person.identifier.ciencia-id211D-C53A-B059
person.identifier.ciencia-id9814-DF91-15FA
person.identifier.orcid0000-0001-9010-2921
person.identifier.orcid0000-0002-0118-9007
person.identifier.orcid0000-0003-1975-5094
person.identifier.orcid0000-0002-2130-8667
person.identifier.ridD-6597-2013
person.identifier.ridD-6188-2013
person.identifier.ridD-6248-2013
person.identifier.ridM-7017-2013
person.identifier.scopus-author-id6603283442
person.identifier.scopus-author-id7101675251
person.identifier.scopus-author-id36841737900
person.identifier.scopus-author-id7005270435
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication3bcd8da3-960c-442f-9fb7-2e680c369a28
relation.isAuthorOfPublication49440195-c1d1-47ff-8c91-5f9c7e49f08e
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relation.isAuthorOfPublication.latestForDiscovery796cdb44-719b-4e76-b6aa-d6c5472409e4

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