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Autologous Platelet Concentrate of 2 nd and 3 rd generations efficacy in the surgical treatment of gingival recession: an overview of systematic reviews

2021-11-01Journal article Open access
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dc.contributor.authorFernandes, Gustavo
dc.contributor.authorSantos, Nuno
dc.contributor.authorSiqueira, Rafael
dc.contributor.authorWang, How Lay
dc.contributor.authorBlanco-Carrion, Juan
dc.contributor.authorFernandes, Juliana
dc.date.accessioned2021-12-06T10:32:20Z
dc.date.available2021-12-06T10:32:20Z
dc.date.issued2021-11-01
dc.description.abstractBackground: Autologous platelet concentrate (APC)/platelet-rich fibrin (PRF) of second and third generations has increased use in periodontics to optimize wound healing. Few systematic reviews (SRs) have reported improved clinical outcomes, while other studies reported significantly better results for the connective tissue graft (CTG). There is still unclear clinical evidence about APC/PRF use to treat gingival recession (GR) defects. Then, the purpose of this SR was to evaluate the use of APC/PRF membranes (2 nd and 3 rd generations) in root coverage (RC) procedures and assess its efficacy as a substitute biomaterial. Materials and Methods: An electronic search was conducted in PubMed, Cochrane Central, Web of Science, Google Scholar, BookSC databases, and gray literature. The search strategy, without date restriction up to April 2020, included keywords as 'platelet-rich fibrin,' 'autologous platelet concentrates,' 'blood,' 'systematic review,' 'periodontics,' 'surgery,' 'tissue,' 'gingiva,' 'gingival recession,' 'connective tissue,' 'graft,' and 'root coverage.' The methodological quality was evaluated through the AMSTAR2, and a population, index test, comparator, outcome strategy was used to assess specific clinical parameters such as recession depth, clinical attachment levels, and RC outcomes. Results: Nine SRs were included. Only three articles described the technique of APC/PRF production. Three studies reported unfavorable outcomes using APC, while six reported favorable results and postoperative discomfort reduction. Articles included in this SRs that provided information about APC/PRF membranes (n = 13) showed no significant difference between APC/PRF and the control group for the parameters analyzed. Conclusions: This implies that APC/PRF may be considered a feasible substitute biomaterial for treating GR defects, although the CTG still provides superior outcomes. Further long-term and controlled studies are needed to verify this finding.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.4103/jisp.jisp_515_20pt_PT
dc.identifier.eid85119498703
dc.identifier.issn0972-124X
dc.identifier.pmcPMC8603797
dc.identifier.pmid34898911
dc.identifier.urihttp://hdl.handle.net/10400.14/36104
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectAutologous platelet concentratept_PT
dc.subjectGingival recessionpt_PT
dc.subjectPeriodontal surgerypt_PT
dc.subjectRoot coveragept_PT
dc.subjectSystematic reviewpt_PT
dc.titleAutologous Platelet Concentrate of 2 nd and 3 rd generations efficacy in the surgical treatment of gingival recession: an overview of systematic reviewspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage479pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage463pt_PT
oaire.citation.titleJournal of Indian Society of Periodontologypt_PT
oaire.citation.volume25pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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