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Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals

2023-12Journal article Open access
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dc.contributor.authorXue, Pei
dc.contributor.authorMerikanto, Ilona
dc.contributor.authorChung, Frances
dc.contributor.authorMorin, Charles M.
dc.contributor.authorEspie, Colin
dc.contributor.authorBjorvatn, Bjørn
dc.contributor.authorCedernaes, Jonathan
dc.contributor.authorLandtblom, Anne Marie
dc.contributor.authorPenzel, Thomas
dc.contributor.authorGennaro, Luigi de
dc.contributor.authorHolzinger, Brigitte
dc.contributor.authorMatsui, Kentaro
dc.contributor.authorHrubos-Strøm, Harald
dc.contributor.authorKorman, Maria
dc.contributor.authorLeger, Damien
dc.contributor.authorMota-Rolim, Sérgio
dc.contributor.authorBolstad, Courtney J.
dc.contributor.authorNadorff, Michael
dc.contributor.authorPlazzi, Giuseppe
dc.contributor.authorReis, Cátia
dc.contributor.authorChan, Rachel Ngan Yin
dc.contributor.authorWing, Yun Kwok
dc.contributor.authorYordanova, Juliana
dc.contributor.authorBjelajac, Adrijana Koscec
dc.contributor.authorInoue, Yuichi
dc.contributor.authorPartinen, Markku
dc.contributor.authorDauvilliers, Yves
dc.contributor.authorBenedict, Christian
dc.date.accessioned2023-02-15T10:09:14Z
dc.date.available2023-02-15T10:09:14Z
dc.date.issued2023-12
dc.description.abstractShort nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18–99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41398-023-02334-4pt_PT
dc.identifier.eid85147176439
dc.identifier.issn2158-3188
dc.identifier.pmcPMC9890416
dc.identifier.pmid36726008
dc.identifier.urihttp://hdl.handle.net/10400.14/40225
dc.identifier.wos000923536600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePersistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individualspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleTranslational Psychiatrypt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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