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Exploring salivary biomarkers in pediatric obesity: a scoping review

2025-06-17Artigo de revisão Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorSabella, Fernanda Maria
dc.contributor.authorKatzenelson, Renata Thomaz
dc.contributor.authorCarvalho, Fabíola Galbiatti de
dc.contributor.authorDuque, Cristiane
dc.contributor.authorDarrieux, Michelle
dc.contributor.authorMarson, Fernando Augusto Lima
dc.contributor.authorParisotto, Thaís Manzano
dc.date.accessioned2025-09-02T11:36:46Z
dc.date.available2025-09-02T11:36:46Z
dc.date.issued2025-06-17
dc.description.abstractChildhood obesity and overweight are linked to subclinical inflammatory conditions. The present manuscript aimed to undertake a scoping review exploring the relationship between childhood obesity and salivary biomarkers to answer the following question: “Are salivary biomarkers trustful factors/indicators for childhood obesity?” The main search terms used were: “obesity and salivary biomarkers and children” (Pubmed, Scielo, Scopus, Embase databases: 1999–2025). Assessed articles were carefully classified according to a predetermined criterion (Newcastle–Ottawa Scale), and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were considered. Papers involving children >13 years, duplicates/triplicates, literature reviews, and non-related to the question addressed were excluded. More than 30 salivary biomarkers were assessed in the thirteen studies appraised. Three studies were rated as having a high level of evidence, two as moderate, and eight as having a low level. Fourteen biomarkers were found to be significantly increased in childhood obesity/overweight (p < 0.05): leptin, insulin, α-amylase, tumor necrosis factor α, interleukin 6, vascular endothelial growth factor-A, C-reactive protein, monocyte chemotactic protein-1, resistin, phosphate, nitric oxide, interleukin 1β, uric acid and fetuin-A; and three were found to be significantly decreased (p < 0.05): adiponectin, secretory immunoglobulin A, and interleukin-12p70. In conclusion, the present review supported the idea that saliva might be a promising diagnostic tool in early life and that it is a significant source of obesity biomarkers in children.eng
dc.identifier.citationSabella, F. M., Katzenelson, R. T., Carvalho, F. G. D., & Duque, C. et al. (2025). Exploring salivary biomarkers in pediatric obesity: a scoping review. International Journal of Molecular Sciences, 26(12), Article 5789. https://doi.org/10.3390/ijms26125789
dc.identifier.doi10.3390/ijms26125789
dc.identifier.eid105008990989
dc.identifier.issn1661-6596
dc.identifier.other1c2a1631-6c28-4929-895f-957c14c25dab
dc.identifier.pmcPMC12193587
dc.identifier.pmid40565251
dc.identifier.urihttp://hdl.handle.net/10400.14/54586
dc.identifier.wos001516124600001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiomarkers
dc.subjectPediatric obesity
dc.subjectSaliva
dc.titleExploring salivary biomarkers in pediatric obesity: a scoping revieweng
dc.typereview article
dspace.entity.typePublication
oaire.citation.issue12
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.citation.volume26
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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