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- Clinical validation of the nursing diagnosis spiritual distress in cancer patients undergoing chemotherapyPublication . Caldeira, Sílvia; Timmins, Fiona; Carvalho, Emília Campos de; Vieira, MargaridaObjective: Validate the nursing diagnosis spiritual distress in cancer patients. Methods: Cross-sectional approach using Richard Fehring's Clinical Diagnostic Validity Model. Findings: The prevalence of diagnosis was 40.8% in a sample of 170 patients. A total of 16 defining characteristics were validated. Expresses suffering had the highest sensitivity value and lack of meaning in life had the highest specificity value. Conclusions: The diagnosis was validated. Cancer patients in spiritual distress are in a state of suffering related to lack of meaning in life. Implications for Practice: Sensitive diagnosis tools and language are required for nurses to make accurate judgments in situations of spiritual distress. Validation in different contexts would increase the clinical evidence of this diagnosis.