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- Nursing interventions for post-intensive care syndrome in follow-up clinics: a scoping reviewPublication . Gonçalves, Telma; Santos, Marta; Pontífice-Sousa, Patrícia; Antunes, Vanessa; Bacalhau, LúciaThe rise in ICU survival rates has introduced new challenges related to the long-term effects of intensive care, known as Post-Intensive Care Syndrome (PICS). Nurses play a key role in these clinics; however, the nature and outcomes of their interventions remain insufficiently understood. Objectives: This review aims to identify nursing interventions for PICS in follow-up clinics. Methods: Using the JBI scoping review methodology, we searched PubMed, Web of Science and CINAHL (via EBSCOhost) in March 2025, and examined grey literature in RCAAP and Open Dissertations (through B-ON). Inclusion criteria, based on JBI’s PCC (Population, Concept, Context), focused on nursing interventions for PICS for patients and families in follow-up. Studies involving children, adolescents, pregnant women, and those receiving end-of-life care were excluded. Results: Encompassing studies from 2005 to 2022 across multiple countries, this review highlights nursing interventions for post-ICU recovery. A total of 394 articles that met our search criteria were found, resulting from searches in the mentioned databases. These were initially exported to Rayyan, and 115 duplicates were removed. The 21 articles that met our inclusion criteria were fully analyzed, and those that effectively answered our questions and met our inclusion criteria were selected. In the end, 9 articles were selected, to which, after an individual analysis of their bibliographic references, 3 more were added, totaling 12 articles submitted to the final analysis. Conclusions: For patients, interventions ranged from debriefing, PICS symptom evaluation, ICU re-visits, health education, cognitive–behavioral therapy and support groups, complemented by home-based physical rehabilitation and virtual reality. Family-focused interventions centered on appointment involvement, educational sessions, patient diary review, and emotional support. These assessments and interventions address the consequences of ICU admission, with the goal of facilitating physical, mental, and emotional rehabilitation of ICU survivors. This review emphasizes the critical role of follow-up consultations in the recovery of both patients and families. A comprehensive assessment using PICS scales and the integration of families into care plans are crucial for optimizing intervention outcomes. Implications for Clinical Practice: The development of evidence-based guidelines for implementation of follow-up clinics for SPICI appointments is necessary.
- WHO's global status report on neurology: mixed messages for people with headache disordersPublication . Lifting The Burden: the Global Campaign against Headache; Gil-Gouveia, Raquel
- Design of thermoreversible peptide loaded liposomes for atopic dermatitisPublication . Carvalho, Laura Judite Benge Dias de; Costa, Eduardo Manuel Aguiar da; Pintado, Maria Manuela EstevezAtopic dermatitis (AD) is a chronic inflammatory skin disorder associated with impaired barrier function, immune dysregulation and intense pruritus, severely affecting patients’ quality of life. Despite its high prevalence, current therapies remain centred on symptomatic control and often show limited efficacy, highlighting the need for safer and more sustainable alternatives. This study explored bioactive marine peptides (<3 kDa) derived from fishery by-products as therapeutic agents, incorporated into liposomal nanosystems designed for topical delivery. The formulations defined as optimal, which included two systems composed of different amounts of lecithin and one containing both lecithin and cholesterol, exhibited encapsulation efficiencies between 89.7% and 91.3% and polydispersity index values ranging from 0.188 to 0.577 at laboratory scale. After scale-up, these same formulations maintained average particle sizes below 20 nm and low PDI (<0.4), with encapsulation efficiencies between 50.8% and 80.9%. The cholesterol-containing system demonstrated the greatest stability and resilience throughout the scale-up process, confirming the importance of moderate cholesterol content in maximising peptide retention and preserving colloidal stability. FTIR and DSC analyses revealed constituent compatibility and bilayer reorganisation without achieving thermoreversibility, as transition temperatures remained above the physiological range. Release studies fitted the Korsmeyer–Peppas model, indicating diffusion-controlled release, with cholesterol promoting a more gradual and sustained peptide delivery. No antimicrobial effects were observed against Staphylococcus aureus. Cytotoxicity was concentration-dependent, with all formulations biocompatible at 0.3 mg/mL, while the free peptide showed no cytotoxicity. Under these conditions, the phospholipid-rich formulation and cholesterol containing formulation induced metabolic stimulation. Overall, this work demonstrates the feasibility of integrating marine peptides into stable liposomal carriers for topical administration. The cholesterol based formulation stands out as the most balanced system in terms of encapsulation, stability and release performance, providing a solid foundation for future nanotechnology driven strategies in AD therapy that also promote sustainable valorisation of marine resources.
- Valorização da funcionalidade da biomassa de chlorellaPublication . Aldana, Paula Andrea Martínez; Barros, Ana Isabel Faustino; Pereira, Camilly FratelliAs microalgas têm ganho crescente relevância devido ao seu elevado valor nutricional e ao potencial para aplicação em produtos alimentares sustentáveis. A Chlorella branca (Chlorella sp. “white variant”), obtida por cultivo heterotrófico e caracterizada pelo baixo teor de clorofila, apresenta vantagens sensoriais face às microalgas verdes convencionais, tornando-se um ingrediente promissor para formulações de base vegetal. Este trabalho foi desenvolvido no âmbito do estágio curricular realizado na Allmicroalgae – Natural Products S.A., e teve como objetivo avaliar o potencial tecnológico e alimentar da biomassa de Chlorella branca. O estudo foi dividido em três partes: (i) análise do efeito da variação do rácio C/N na composição da biomassa, (ii) caracterização das propriedades tecno-funcionais da biomassa húmida e em pó e (iii) incorporação da biomassa numa bebida vegetal. Na primeira parte verificaram-se alterações no teor de amido e proteína em função do rácio C/N, embora esses efeitos não tenham sido reproduzidos à escala de fermentador. A segunda parte mostrou que a biomassa apresenta propriedades tecnológicas relevantes, nomeadamente solubilidade dependente da temperatura e elevada capacidade emulsificante, com a biomassa seca a revelar maior estabilidade em emulsão. A análise colorimétrica indicou ainda boa estabilidade cromática em condições térmicas moderadas. Na terceira parte, a formulação de uma bebida vegetal contendo 3% de biomassa em pó demonstrou um perfil nutricional favorável, permitindo alegações nutricionais de: “fonte de fibra”, “fonte de proteína” e “alto teor de vitamina B12”. Contudo, a avaliação sensorial revelou uma diminuição da aceitação global com a adição de Chlorella branca, especialmente ao nível do sabor, textura e apreciação global, quando comparada com a bebida base e a referência comercial. Em conclusão, a Chlorella branca apresenta potencial tecnológico para aplicação alimentar, sobretudo como agente funcional e emulsificante natural. No entanto, o impacto sensorial observado realça a necessidade de otimização futura das formulações para melhorar a aceitação do consumidor.