Browsing by Issue Date, starting with "2023-08-01"
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- Proteostasis networks in aging: novel insights from text-mining approachesPublication . Neves, Diogo; Duarte-Pereira, Sara; Matos, Sérgio; Silva, Raquel M.Aging is a topic of paramount importance in an increasingly elderly society and has been the focus of extensive research. Protein homeostasis (proteostasis) decline is a hallmark in aging and several age-related diseases, but which specific proteins and mechanisms are involved in proteostasis (de)regulation during the aging process remain largely unknown. Here, we used different text-mining tools complemented with protein–protein interaction data to address this complex topic. Analysis of the integrated protein interaction networks identified novel proteins and pathways associated to proteostasis mechanisms and aging or age-related disorders, indicating that this approach is useful to identify previously unknown links and for retrieving information of potential novel biomarkers or therapeutic targets.
- Mechanical and contact characteristics of foam materials within wound dressings: theoretical and practical considerations in treatmentPublication . Gefen, Amit; Alves, Paulo; Beeckman, Dimitri; Lázaro-Martínez, José Luis; Lev-Tov, Hadar; Najafi, Bijan; Swanson, Terry; Woo, KevinIn the treatment of acute and chronic wounds, the clinical performance of a given foam-based dressing, and, ultimately, the wound healing and cost of care outcomes are strongly influenced by the mechanical performance of the foam material/s within that dressing. Most aspects of the mechanical performance of foam materials, for example, their stiffness, frictional properties, conformability, swelling characteristics and durability, and the overall mechanical protection provided by a foam-based dressing to a wound strongly depend on the microstructure of the foam components, particularly on their microtopography, density and porosity. This article, therefore, provides, for the first time, a comprehensive, self-inclusive compilation of clinically relevant theoretical and practical considerations, based on published analytical and experimental research as well as clinical experience related to the mechanical performance of foams in foam-based wound dressings. The current bioengineering information is useful for establishing understanding of the importance of mechanical properties of foams in foam-based dressings among clinicians and researchers in industry and academia, and other potential stakeholders in the wound care field, for example, regulators and buyers. This information is also particularly important for the development of standardised test methods for the evaluation of foam-based wound dressings and resulting standard mechanical performance metrics for these dressings.
- Combining high pressure and electric fields towards nannochloropsis oculata eicosapentaenoic acid-rich extractsPublication . Sousa, Sérgio; Carvalho, Ana P.; Pinto, Carlos A.; Amaral, Renata A.; Saraiva, Jorge A.; Pereira, Ricardo N.; Vicente, António A.; Freitas, Ana C.; Gomes, Ana M.Nannochloropsis oculata is naturally rich in eicosapentaenoic acid (EPA). To turn this microalga into an economically viable source for commercial applications, extraction efficiency must be achieved. Pursuing this goal, emerging technologies such as high hydrostatic pressure (HHP) and moderate electric fields (MEF) were tested, aiming to increase EPA accessibility and subsequent extraction yields. The innovative approach used in this study combined these technologies and associated tailored, less hazardous different solvent mixtures (SM) with distinct polarity indexes. Although the classical Folch SM with chloroform: methanol (PI 4.4) provided the highest yield concerning total lipids (166.4 mglipid/gbiomass), diethyl ether: ethanol (PI 3.6) presented statistically higher values in terms of EPA per biomass, corresponding to 1.3-fold increase. When SM were used in HHP and MEF, neither technology independently improved EPA extraction yields, although the sequential combination of technologies did result in 62% increment in EPA extraction. Overall, the SM and extraction methodologies tested (HHP—200 MPa, 21 °C, 15 min, followed by MEF processing at 40 °C, 15 min) enabled increased EPA extraction yields from wet N. oculata biomass. These findings are of high relevance for the food and pharmaceutical industries, providing viable alternatives to the “classical” extraction methodologies and solvents, with increased yields and lower environmental impact.
- What do we know about experiencing the end-of-life in burn intensive care units? a scoping reviewPublication . Ribeiro, André Filipe; Pereira, Sandra Martins; Nunes, Rui; Hernández-Marrero, PabloObjectives: To review and synthetize the evidence on end-of-life in burn intensive care units about (i) the characteristics of end-of-life in burn intensive care units, (ii) the symptom control provided to burned patients facing dying and death in this context, and (iii) the concept, models and designs of the care provided. Methods: Systematically conducted scoping review, following Arksey and O'Malley's framework. Preferred Reporting Items for Systemic Reviews extension for Scoping Reviews was used as a reporting guideline. Searches were performed in three databases, with no time restriction and up to September 2021. Results: 16,287 documents identified; thirteen (13) selected for analysis and synthesis. Three key themes emerged: (i) characteristics of the end-of-life in burn intensive care units, including end-of-life decisions, decision-making processes, causes and trajectories of death; (ii) symptom control at the end-of-life in burn intensive care units focusing on patients’ comfort; and (iii) concepts, models, and designs of the care provided to burned patients at the end-of-life, mainly care approaches, provision of care and palliative care.Significance of Results: End-of-life care is a major step in the care provided to critically ill burned patients. Dying and death in burn intensive care units are often preceded by end-of-life decisions, namely forgoing treatment, and do-not-attempt to resuscitate. Different dying trajectories were described, suggesting the possibility to develop further studies to identify triggers for palliative care referral. Symptom control was not described in detail. Palliative care was rarely involved in end-of-life care for these patients. This review highlights the need for early and high-quality palliative and end-of-life care in the trajectories of critically ill burned patients, leading to an improved perception of end-of-life in burn intensive care units. Further research is needed to study the best way to provide optimal end-of-life care and foster integrated palliative care in burn intensive care units.
- A figure is worth a thousand words: the role of visualization in paradox theorizingPublication . Pradies, Camille; Berti, Marco; Cunha, Miguel Pina e; Rego, Arménio; Tunarosa, Andrea; Clegg, Stewart R.Visualization (i.e., the use of figures and images to represent findings and conceptual models) is central to theorizing. Yet, by focusing solely on the textual content of papers, analysis has inadvertently marginalized the graphic representations of key ideas. We review the paradox literature not just in terms of what authors have written but also how they have visualized models concisely. An analysis of figures in paradox articles captures the essential role that visuals play in our understanding of competing tensions, leveraging the power of imagery. We explore paradox visually, searching for the figurative materialization of paradox; more particularly, we seek visual signs that render abstract ideas more saliently and concretely. We contribute to paradox theory in three ways. First, we show how visuals constitute the lynchpin between convergent and divergent forces, allowing scholars to simultaneously reinforce and challenge current understanding. Second, we offer a tool for scholars to theorize competing demands based on three key antinomies, or dualities, that define the terrain of research in our field. Third, we reveal the performative effect of figures by identifying the ongoing dominance of certain classes of paradox visuals, which allows us to point to uncharted territories for paradox research.
- Effect of splinting scan bodies on the trueness of complete-arch digital implant scans with 5 different intraoral scannersPublication . Azevedo, Luís; Marques, Tiago; Karasan, Duygu; Fehmer, Vincent; Sailer, Irena; Correia, André; Gómez-Polo, MiguelStatement of problem: The absence of fixed reference points can affect the trueness of complete-arch intraoral digital implant scans. The effect of splinting intraoral scan bodies (ISBs) or the inclusion of artificial landmarks (AL) on the trueness of complete-arch digital implant scans is still unclear. Purpose: The purpose of this study was to analyze the effect of splinting ISBs or the inclusion of AL on the trueness of complete-arch digital implant scans with 5 intraoral scanners (IOSs). Material and methods: Six tissue-level dental implants (Straumann Tissue Level) were placed in an edentulous patient, and the correspondent definitive cast was digitized with a desktop scanner (IScan4D LS3i) to obtain the reference digital cast. Digital scans (n=10) were performed with 5 IOSs: TRIOS 4, Virtuo Vivo, Medit i700, iTero Element 5D, and Cerec Primescan. Three different scanning techniques were evaluated: conventional (cIOSs), splinted (sIOSs), and AL (AL-IOSs). The scan data obtained were imported into a metrology software program and superimposed to the reference digital cast by using a best-fit algorithm. The overall deviations of the positions of the ISBs were evaluated by using the root-mean-square (RMS) error (α=.05). Results: The mean ±standard deviation trueness values for the cIOSs, sIOSs, and AL-IOSs groups were 48 ±8 µm, 53 ±7 µm, and 49 ±11 µm, respectively, with no statistically significant differences (P=.06). Significant differences were found for the IOSs used with each technique (P<.001). Primescan (27 ±4 µm cIOSs; 28 ±3 µm sIOSs; 31 ±3 µm AL-IOSs) showed significantly higher trueness than iTero 5D (47 ±5 µm cIOSs; 47 ±4 µm sIOSs; 50 ±6 µm AL-IOSs) (P=.002) and TRIOS 4 (93 ±18 µm cIOSs; 76 ±18 µm sIOSs; 107 ±13 µm AL-IOSs) (P=.001) for all techniques. In addition, no significant differences were found between the techniques by using iTero 5D or Primescan (P=.348 and P=.059, respectively). Conclusions: The cIOSs, sIOSs, and AL-IOSs techniques showed similar trueness. The IOS used influenced the trueness of complete-arch digital implant scans.
- Green roofs as an urban NBS strategy for rainwater retention: influencing factors - a reviewPublication . Monteiro, Cristina M.; Mendes, Ana Mafalda; Santos, CristinaThere has been a rapid development in studies of nature-based solutions (NbS) worldwide, which reveals the potential of this type of solution and the high level of interest in its implementation to improve the resilience of cities. Much relevant information and many important results are being published, and it is now possible to see their diverse benefits and complexity. Several authors highlight their role in urban areas not just in temperature control, but also in human health, ecosystem development and water management. However, in the current reality of cities, where water use is being (and will be) constantly challenged, analyzing NbS advantages for the urban water cycle is crucial. This study performed an intense review of the NbS literature from 2000 to 2021, to identify their contributions to the improvement of urban water cycle management and thus provide a solid information base for distinct entities (public institutions, private investors and the urban population in general) to disseminate, apply and justify their implementation. In general terms, the urban water cycle embraces not only the abstraction of water for urban consumption, but also its return to nature and all the stages in between, including water reuse and stormwater management. This review will highlight the important benefits that NbS in general, and green roofs in particular, provide to urban stormwater control, a key factor that contributes to urban sustainability and resilience in order to face future climate challenges. The novelty of the present review paper falls within the conclusions regarding the crucial role that NbS develop in urban water management and the main features that must be tested and technically enhanced to improve their functioning.
- A comparison among optimization software to solve bi-objective sectorization problemPublication . Teymourifar, AydinIn this study, we compare the performance of optimization software to solve the bi-objective sectorization problem. The used solution method is based on an approach that has not been used before in the literature on sectorization, in which, the bi-objective model is transformed into single-objective ones, whose results are regarded as ideal points for the objective functions in the bi-objective model. Anti-ideal points are also searched similarly. Then, using the ideal and anti-ideal points, the bi-objective model is redefined as a single-objective one and solved. The difficulties of solving the models, which are basically non-linear, are discussed. Furthermore, the models are linearized, in which case how the number of variables and constraints changes is discussed. Mathematical models are implemented in Python's Pulp library, Lingo, IBM ILOG CPLEX Optimization Studio, and GAMS software, and the obtained results are presented. Furthermore, metaheuristics available in Python's Pymoo library are utilized to solve the models' single- and bi-objective versions. In the experimental results section, benchmarks of different sizes are derived for the problem, and the results are presented. It is observed that the solvers do not perform satisfactorily in solving models; of all of them, GAMS achieves the best results. The utilized metaheuristics from the Pymoo library gain feasible results in reasonable times. In the conclusion section, suggestions are given for solving similar problems. Furthermore, this article summarizes the managerial applications of the sectorization problems.
- Attention trajectories capture utility accumulation and predict brand choicePublication . Martinovici, Ana; Pieters, Rik; Erdem, TülinTrajectories of attention capture the accumulation of brand utility during complex decision-making tasks. Thus, attention trajectories, as reflected in eye movements, predict the final brand choice of 85% of consumers before they implement it. Even when observing eye movements in only the first quarter of the decision process, attention already predicts brand choice much better (45%) than chance levels (20%). This superior prediction performance is due to a “double attention lift” for the chosen brand: The chosen brand receives progressively more attention toward the moment of choice, and more of this attention is devoted to integrating information about the brand rather than to comparing it with other options. In contrast, the currently owned brand grabs attention early in the task, and its attention gain persists for brand-loyal consumers and shifts for brand-switching consumers. A new attention and choice model used in tandem with the Bayesian K-fold cross-validation methodology on eye-tracking data from 325 representative consumers uncovered these attention trajectory effects. The findings contribute to closing important knowledge gaps in the attention and choice literature and have implications for marketing research and managerial practice.