Browsing by Issue Date, starting with "2023-03-04"
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- Spiritual care in the undergraduate nursing degree in PortugalPublication . Afonso, Ana; Sitefane, Sara; Rabiais, Isabel; Nunes, Lucília; Caldeira, SílviaSpiritual care is an essential dimension of holistic care. The purpose of this study was to identify the explicit presence of spiritual care in undergraduate nursing curricula in Portugal. Data were collected through a search in the syllabuses of undergraduate nursing degrees as displayed on the websites of higher education institutions (HEI). Of the 36 HEI, none had a course unit entitled (with title or subtitle) spirituality or spiritual care, even though all the HEI describe a common mission related to preparing nursing students for holistic care.
- Functional ingredients and additives from lemon by-products and their applications in food preservation: a reviewPublication . Magalhães, Daniela; Vilas-Boas, Ana A.; Teixeira, Paula; Pintado, ManuelaCitrus trees are among the most abundant fruit trees in the world, with an annual production of around 124 million tonnes. Lemons and limes are among the most significant contributors, producing nearly 16 million tonnes per year. The processing and consumption of citrus fruits generates a significant amount of waste, including peels, pulp, seeds, and pomace, which represents about 50% of the fresh fruit. Citrus limon (C. limon) by-products are composed of significant amounts of bioactive compounds, such as phenolic compounds, carotenoids, vitamins, essential oils, and fibres, which give them nutritional value and health benefits such as antimicrobial and antioxidant properties. These by-products, which are typically discarded as waste in the environment, can be explored to produce new functional ingredients, a desirable approach from a circular economy perspective. The present review systematically summarizes the potential high-biological-value components extracted from by-products to achieve a zero-waste goal, focusing on the recovery of three main fractions: essential oils, phenolic compounds, and dietary fibres, present in C. limon by-products, and their applications in food preservation.
- Differential lipid accumulation on HepG2 cells triggered by palmitic and linoleic fatty acids exposurePublication . Teixeira, Francisca S.; Pimentel, Lígia L.; Vidigal, Susana S. M. P.; Azevedo-Silva, João; Pintado, Manuela E.; Rodríguez-Alcalá, Luís M.Lipid metabolism pathways such as β-oxidation, lipolysis and, lipogenesis, are mainly associated with normal liver function. However, steatosis is a growing pathology caused by the accumulation of lipids in hepatic cells due to increased lipogenesis, dysregulated lipid metabolism, and/or reduced lipolysis. Accordingly, this investigation hypothesizes a selective in vitro accumulation of palmitic and linoleic fatty acids on hepatocytes. After assessing the metabolic inhibition, apoptotic effect, and reactive oxygen species (ROS) generation by linoleic (LA) and palmitic (PA) fatty acids, HepG2 cells were exposed to different ratios of LA and PA to study the lipid accumulation using the lipophilic dye Oil Red O. Lipidomic studies were also carried out after lipid isolation. Results revealed that LA was highly accumulated and induced ROS production when compared to PA. Lipid profile modifications were observed after LA:PA 1:1 (v/v) exposure, which led to a four-fold increase in triglycerides (TGs) (mainly in linoleic acid-containing species), as well as a increase in cholesterol and polyunsaturated fatty acids (PUFA) content when compared to the control cells. The present work highlights the importance of balancing both PA and LA fatty acids concentrations in HepG2 cells to maintain normal levels of free fatty acids (FFAs), cholesterol, and TGs and to minimize some of the observed in vitro effects (i.e., apoptosis, ROS generation and lipid accumulation) caused by these fatty acids.