Browsing by Issue Date, starting with "2022-08-29"
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- Novos paradigmas ecoteológicos em tempos de risco: ciência e ecologia em diálogo com a teologiaPublication . Varanda, Maria Isabel PereiraEste estudo identifica uma série de questões epistemológicas e fenomenológicas que convocam a ecologia e a teologia e que têm a ver com as experiências sistémicas de falência, desintegração e desmoronamento da vida quotidiana e da própria sobrevivência da vida no planeta terra, no século XXI. Procura discernir novos paradigmas com valor heurístico e operante nos processos de viragem civilizacional; novos paradigmas como lentes para melhor detetar-sentir-conhecer o planeta e a vida no planeta, numa linha de sobrevivência, de homeostasia e de salvação da realidade total. Tendo como "coerenciadores" os conceitos de Great Turning e Deep Incarnation, pretende sustentar a articulação do conceito de ecologia integral (Laudato Si') com a ecologia profunda (Arne Naess) e com as bases fundacionais do Cristianismo. Do diálogo com alguns elementos básicos da Neurobiologia resulta a identificação de uma eco-teologia-integral-profunda, que demonstra o seu caráter operatório no mundo de hoje e que compromete, de modo vinculativo, o humano com a Terra e com a boa governança da vida do ecossistema global.
- Watchdogging populism: journalistic roles conception, performance and negotiation in reporting the far-right in PortugalPublication . Novais, Rui AlexandreThe article aims to unpack the press reporting of far-right populism invested in its journalistic roles, as manifested in the watchdog performance by the leading Portuguese newsmagazine Visão in a series of feature articles on the emergent Chega party. Drawing on an original combination of methodologies comprising surveys, rhetorical analysis, and qualitative interviewing, it concludes that Visão adopts an interventionist mode of the watchdog role in the reporting. It also validates the need to integrate a negotiative assessment of the role orientation and reporting practive to fill both the general ideal-practive gap of the journalistic roles and the specific ideal-performance of the watchdog role.
- Genetic variants of ABC and SLC transporter genes and chronic myeloid leukaemia: impact on susceptibility and prognosisPublication . Alves, Raquel; Goncalves, Ana Cristina; Jorge, Joana; Marques, Gilberto; Ribeiro, André B.; Tenreiro, Rita; Coucelo, Margarida; Diamond, Joana; Oliveiros, Bárbara; Pereira, Amélia; Freitas-Tavares, Paulo; Almeida, António M.; Sarmento-Ribeiro, Ana BelaSolute carrier (SLC) and ATP-binding cassette (ABC) transporters comprise a variety of proteins expressed on cell membranes responsible for intrusion or extrusion of substrates, respectively, including nutrients, xenobiotics, and chemotherapeutic agents. These transporters mediate the cellular disposition of tyrosine kinase inhibitors (TKIs), and their genetic variants could affect its function, potentially predisposing patients to chronic myeloid leukaemia (CML) and modulating treatment response. We explored the impact of genetic variability (single nucleotide variants—SNVs) of drug transporter genes (ABCB1, ABCG2, SLC22A1, and SLC22A5) on CML susceptibility, drug response, and BCR-ABL1 mutation status. We genotyped 10 SNVs by tetra-primers-AMRS-PCR in 198 CML patients and 404 controls, and assessed their role in CML susceptibility and prognosis. We identified five SNVs associated with CML predisposition, with some variants increasing disease risk, including TT genotype ABCB1 (rs1045642), and others showing a protective effect (GG genotype SLC22A5 rs274558). We also observed different haplotypes and genotypic profiles associated with CML predisposition. Relating to drug response impact, we found that CML patients with the CC genotype (rs2231142 ABCG2) had an increased risk of TKI resistance (six-fold). Additionally, CML patients carrying the CG genotype (rs683369 SLC22A1) presented a 4.54-fold higher risk of BCR-ABL1 mutations. Our results suggest that drug transporters’ SNVs might be involved in CML susceptibility and TKI response, and predict the risk of BCR-ABL1 mutations, highlighting the impact that SNVs could have in therapeutic selection.
- Frequency of nurse-provided spiritual care: An international comparisonPublication . Taylor, Elizabeth Johnston; Parinas, Sabina; Mamier, Iris; Atarhim, Mohd Arif; Angeles, Leonardo; Aslan, Hakime; Akturk, Ummuhan; Erci, Behice; Soriano, Gil; Sinaga, Juniarta; Chen, Yi-Heng; Merati-Fashi, Fatemeh; Odonel, Girlie; Neathery, Melissa; Permatasari, Winda; Ricci-Allegra, Patricia; Foith, Joanne; Caldeira, Sílvia; Dehom, SalemAims and objectives: To compare the frequency of nurse-provided spiritual care across diverse cultures. Background: Given an ethical imperative to respect patient spirituality and religiosity, nurses are increasingly taught and expected to provide spiritual care. Although nurses report positive attitudes toward spiritual care, they typically self-report providing it infrequently. Evidence about the reported frequency of spiritual care is constrained by substantial variation in its measurement. Design: This cross-sectional, descriptive study involved secondary analysis of data collected in multiple sites globally using one quantitative instrument. Methods: Data were collected from practicing nurses using the Nurse Spiritual Care Therapeutics Scale and analysed using descriptive statistics and a meta-analysis procedure with random-effect modelling. Datasets from 16 studies completed in Indonesia, Iran, Malaysia, Philippines, Portugal, Taiwan, Turkey and the United States contributed to a pooled sample (n = 4062). STROBE guidelines for cross-sectional observational studies were observed. Results: Spiritual care varied between countries and within countries. It was slightly more frequent within Islamic cultures compared with predominantly Christian cultures. Likewise, frequency of spiritual care differed between nurses in palliative care, predominantly hospital/inpatient settings, and skilled nursing homes. Overall, “Remaining present…” was the most frequent therapeutic, whereas documenting spiritual care and making arrangements for the patient's clergy or a chaplain to visit were among the most infrequent therapeutics. Conclusions: In widely varying degrees of frequency, nurses around the world provide care that is cognisant of the spiritual and religious responses to living with health challenges. Future research should be designed to adjust for the multiple factors that may contribute to nurses providing spiritual care. Relevance to clinical practice: Findings offer a benchmark and begin to inform nurse leaders about what may be normative in practice. They also encourage nurses providing direct patient care that they are not alone and inform educators about what instruction future nurses require.