Browsing by Issue Date, starting with "2021-10-01"
Now showing 1 - 10 of 11
Results Per Page
Sort Options
- Effect of customized healing abutments on the peri-implant linear and volumetric tissue changes at maxillary immediate implant sites: a 1-year prospective randomized clinical trialPublication . Fernandes, Danilo; Nunes, Sílvia; López-Castro, Gonzalo; Marques, Tiago; Montero, Javier; Borges, TiagoBackground: Immediate implant placement (IIP) associated with the use of bone substitutes and collagen matrices (CM) seems to reduce the amount of resorption at peri-implant areas. Recently, customized healing abutments (CA) appeared as another solution in order to seal the socket and preserve the original soft tissue contour. Purpose: To evaluate peri-implant tissues dimensional changes after using customized healing abutments compared with the use of xenogeneic collagen matrices as socket sealing options in flapless maxillary immediate implant placement. Material and methods: The present study was designed as a prospective, randomized, controlled clinical trial. Patients were allocated into two groups depending on the socket sealing option: in the CM group a collagen matrix was used and in the CA group a customized abutment. Digital impressions were taken prior to extraction, 1, 4, and 12 months after implant insertion and the digital files allowed to evaluate linear buccal changes (MBC) and the buccal volumetric variation (BVv) between the different time points at peri-implant tissue areas. Additionally, mucosa variation was computed assessing the papilla presence and the midfacial mucosa height. Statistical significance was set at 0.05. Results: Twenty-eight patients were observed during a 12-month period. Significant differences between mean values of BVv at the first month were observed at the CM and CA group (−9.75 ± 6.65% and −4.76 ± 5.29%, respectively) (p = 0.043). At the 1-year follow-up, no significant differences were found in terms of BVv between the two groups, although the thin bone phenotype (≤1 mm) significantly influenced the volumetric variations that occurred in each group. No significant differences were noticed in midfacial mucosa and papillae alteration between groups, after 1 year of treatment. Conclusion: Both treatment options are predictable solutions for socket sealing in IIP, although a higher volumetric variation can be expected in the presence of thin bone phenotypes.
- Estabelecimentos estáveis híbridos : à luz do relatório "Neutralising the Effects of Branch Mismatch Arrangements, Action 2 : inclusive Framework on BEPS" e da ATAD IIPublication . López Malca, Mariafé; Courinha, Gustavo André Simão Lopes
- Impacto económico e social da sinistralidade rodoviária em PortugalPublication . Silva, Carlos Manuel Pereira da; Bravo, Jorge Miguel Ventura; Gonçalves, João Manuel
- The role of cognitive reserve in moderating the cognitive effects of chemotherapy in breast cancerPublication . Manica, Maria Isabel Fernandes; Lemos, Raquel; Nunes, Maria VâniaThe effect of cancer treatments in cognition has been a matter of scientifical debate for several years. An early identification of risk/protective factors that may interact with this cognitive impact could lead to better quality of life during and after oncological treatments. Cognitive reserve is a factor mostly known in the neurodegenerative context as a moderating factor between brain pathology and its clinical manifestations. Although already studied in the oncological context, there is no record that a more comprehensive assessment model for Cognitive Reserve has been used. CRIq is a socio-behavioral questionnaire that estimates an individual's level of cognitive reserve by collecting information related to their entire adult life. The main objective of this work is to assess the differences in cognitive functioning, through the neuropsychological performance, before treatment and six months after its beginning, as well as to understand the role of cognitive reserve as a moderator factor of these possible changes. Thirty-two women diagnosed with early breast cancer and indicated for chemotherapy treatment were recruited. Results showed a significant relationship between cognitive reserve and cognitive functioning prior to chemotherapy, but this effect was not seen at 6 months. There were no cognitive changes between the two moments; however, there was an improvement in performance in three cognitive measures at six months compared to the first assessment. Other cognitive reserve factors may interact with cognitive functioning than those assessed in the CRIq and practice effects may have been involved in the cognitive performance improvement.
- Comparative life cycle assessment of plant and beef-based patties, including carbon opportunity costsPublication . Saget, Sophie; Costa, Marcela Porto; Santos, Carla Sancho; Vasconcelos, Marta; Styles, David; Williams, MikeLegume-derived foods have been shown to have comparatively low greenhouse gas (GHG) intensities whilst providing high amounts of nutrients. However, processing legumes into meat analogues can incur significant energy costs. Here, we undertake a comprehensive life cycle assessment of plant-based and (Brazilian and Irish) beef burger patties. Sixteen impact categories are supplemented with the carbon opportunity cost of land occupation, and benchmarked against nutrient density units (NDU) to provide holistic evidence on the potential contribution of plant-based patties to environmentally-sustainable nutritional density. Plant-based patties have a smaller environmental footprint across most categories, including a 77% smaller climate change burden, but incur 8% more energy use compared with Brazilian beef patties. Normalised scores (person equivalents) were significantly larger (p < 0.05) for the beef products across key categories including land use, acidification, and marine and terrestrial eutrophication. Sensitivity analyses indicated significant variance across impact categories if beef cattle are reared in South Africa, France or the United States, including a 16-fold difference in land occupation. Biophysical allocation of co-products reduced environmental burdens of beef burgers. However, owing to a 68% higher NDU per serving, reflecting higher fibre and essential fatty acid content, plant-based patties are associated with 81–87% less climate change and 92–95% less marine eutrophication per NDU compared with beef burger patties. Accounting for carbon opportunity cost of land further increased the climate change advantage of plant-based patties by 25–44%. A simple extrapolation indicates that switching from beef to vegetable patties in the UK could save between 9.5 and 11 million tonnes CO2e annually, representing up to 2.4% of territorial GHG emissions.
- Sediments in the mangrove areas contribute to the removal of endocrine disrupting chemicals in coastal sediments of Macau SAR, China, and harbour microbial communities capable of degrading E2, EE2, BPA and BPSPublication . Moreira, Irina S.; Lebel, Alexandre; Peng, Xianzhi; Castro, Paula M. L.; Gonçalves, DavidThe occurrence of endocrine disrupting chemicals (EDCs) is a major issue for marine and coastal environments in the proximity of urban areas. The occurrence of EDCs in the Pearl River Delta region is well documented but specific data related to Macao is unavailable. The levels of bisphenol-A (BPA), estrone (E1), 17α-estradiol (αE2), 17β-estradiol (E2), estriol (E3), and 17α-ethynylestradiol (EE2) were measured in sediment samples collected along the coastline of Macao. BPA was found in all 45 collected samples with lower BPA concentrations associated to the presence of mangrove trees. Biodegradation assays were performed to evaluate the capacity of the microbial communities of the surveyed ecosystems to degrade BPA and its analogue BPS. Using sediments collected at a WWTP discharge point as inoculum, at a concentration of 2 mg l−1 complete removal of BPA was observed within 6 days, whereas for the same concentration BPS removal was of 95% after 10 days, which is particularly interesting since this compound is considered recalcitrant to biodegradation and likely to accumulate in the environment. Supplementation with BPA improved the degradation of bisphenol-S (BPS). Aiming at the isolation of EDCs-degrading bacteria, enrichments were established with sediments supplied with BPA, BPS, E2 and EE2, which led to the isolation of a bacterial strain, identified as Rhodoccoccus sp. ED55, able to degrade the four compounds at different extents. The isolated strain represents a valuable candidate for bioremediation of contaminated soils and waters.
- From international policy to goal-setting global governance : are the UN sustainable development goals an effective legal tool? : a comparison with the Paris AgreementPublication . Constantinescu, Maria-Alexandra; Matias, Gonçalo Nuno da Cruz Saraiva
- Advances in industrial and environmental microbiologyPublication . Ciesielski, Slawomir; Vaz-Moreira, Ivone
- Resistance to tyrosine kinase inhibitors in chronic myeloid leukemia — from molecular mechanisms to clinical relevancePublication . Alves, Raquel; Gonçalves, Ana Cristina; Rutella, Sergio; Almeida, António M.; Rivas, Javier De Las; Trougakos, Ioannis P.; Ribeiro, Ana Bela SarmentoResistance to targeted therapies is a complex and multifactorial process that culminates in the selection of a cancer clone with the ability to evade treatment. Chronic myeloid leukemia (CML) was the first malignancy recognized to be associated with a genetic alteration, the t(9;22)(q34;q11). This translocation originates the BCR-ABL1 fusion gene, encoding the cytoplasmic chimeric BCR-ABL1 protein that displays an abnormally high tyrosine kinase activity. Although the vast majority of patients with CML respond to Imatinib, a tyrosine kinase inhibitor (TKI), resistance might occur either de novo or during treatment. In CML, the TKI resistance mechanisms are usually subdivided into BCR-ABL1-dependent and independent mechanisms. Furthermore, patients’ compliance/adherence to therapy is critical to CML management. Techniques with enhanced sensitivity like NGS and dPCR, the use of artificial intelligence (AI) techniques, and the development of mathematical modeling and computational prediction methods could reveal the underlying mechanisms of drug resistance and facilitate the design of more effective treatment strategies for improving drug efficacy in CML patients. Here we review the molecular mechanisms and other factors involved in resistance to TKIs in CML and the new methodologies to access these mechanisms, and the therapeutic approaches to circumvent TKI resistance.
- Preservação de patrimônio bibliográfico em Museus-Casas : o Museu Casa de Rui BarbosaPublication . Gonçalves, Edmar Moraes; Barata, Carolina Sofia Sarrazola; Pereira, Henrique ManuelA tese reflete sobre a preservação de bibliotecas históricas situadas em meio a circuitos de museus-casas, onde as encadernações de seus livros se revestem de especial significado. Comenta sobre o museu-casa como uma tipologia especial de museu, onde as bibliotecas precisam ser tratadas sob os princípios da conservação e restauração. Discorre sobre as ações de preservação desenvolvidas para proteção do acervo bibliográfico do Museu Casa de Rui Barbosa, bem como sobre as características de suas encadernações. Apresenta os resultados do diagnóstico realizado em um grupo de livros e as intervenções realizadas para resgatar suas características originais e identidade histórica.