Percorrer por autor "Vala, Helena"
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- CanisOme - the protein signatures of Canis lupus familiaris diseasesPublication . Fernandes, Mónica; Rosa, Nuno; Esteves, Eduardo; Correia, Maria José; Arrais, Joel; Ribeiro, Paulo; Vala, Helena; Barros, MarleneAlthough the applications of Proteomics in Human Biomedicine have been explored for some time now, in animal and veterinary research, the potential of this resource has just started to be explored, especially when companion animal health is considered. In the last years, knowledge on the Canis lupus familiaris proteome has been accumulating in the literature and a resource compiling all this information and critically reviewing it was lacking. This article presents such a resource for the first time. CanisOme is a database of all proteins identified in Canis lupus familiaris tissues, either in health or in disease, annotated with information on the proteins present on the sample and on the donors. This database reunites information on 549 proteins, associated with 63 dog diseases and 33 dog breeds. Examples of how this information may be used to produce new hypothesis on disease mechanisms is presented both through the functional analysis of the proteins quantified in canine cutaneous mast cell tumors and through the study of the interactome of C. lupus familiaris and Leishmania infantum. Therefore, the usefulness of CanisOme for researchers looking for protein biomarkers in dogs and interested in a comprehensive analysis of disease mechanisms is demonstrated. Biological significance: This paper presents CanisOme, a database of proteomic studies with relevant protein annotation, allowing the enlightenment of disease mechanisms and the discovery of novel disease biomarkers for C. lupus familiaris. This knowledge is important not only for the improvement of animal health but also for the use of dogs as models for human health studies.
- OvinOralOme: Ovis aries oral proteome databasePublication . Esteves, Eduardo; Rosa, Nuno; Correia, M. J.; Vala, Helena; Barros, Marlene
- OvinOralOme: Ovis aries oral proteome databasePublication . Esteves, Eduardo; Rosa, Nuno; Correia, M. J.; Vala, Helena; Barros, MarleneThe present study aims to develop a database transferring the methodology used in humans to the storage and cataloguing of proteins present in the oral cavity and other tissues of Ovis aries. This database will be essential to develop diagnosis methods to be applied to living animals targeting the most prevalent diseases affecting the stock in Serra da Estrela region.
- OvisOme: atualização da base de dados de Ovis ariesPublication . Esteves, Eduardo; Fernandes, Mónica; Rosa, Nuno; Correia, Maria José; Vala, Helena; Barros, Marlene
- OvisOme: atualização da base de dados de Ovis ariesPublication . Esteves, Eduardo; Fernandes, Mónica; Rosa, Nuno; Correia, Maria José; Vala, Helena; Barros, MarleneDatabases are essential to store, annotate and provide the scientific community with all the information gathered by different omics studies, so that it can be used to understand the physio-pathological mechanisms underlying sheep diseases, as well as to develop new and improved diagnostic, prognostic and therapeutic strategies. OvisOme is a database that integrates the information produced by proteomics and studies that identify and quantify specific proteins in diseases of Ovis aries. When compared to other proteomics databases, the OvisOme stores and displays more information than other databases not specific for sheep, such as UniPro.