Browsing by Author "Teixeira, Diana"
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- A digital tool for self-reporting cardiovascular risk factors: the RADICAL studyPublication . Santos, José Ferreira; Castela, Inês; Madeira, Sara Gamboa; Furtado, Sofia; Pereira, Hugo Vieira; Teixeira, Diana; Dores, HélderAims: Cardiovascular diseases remain the leading cause of death worldwide. Risk stratification and early interventions are essential to overcome this reality. The RADICAL Study (Risk Assessment via Digital Input for Cardiovascular And Lifestyle Factors) aimed to evaluate the prevalence of self-reported cardiovascular risk factors in individuals without known cardiovascular disease using a digital tool. Methods and results: A digital self-reported cardiovascular risk stratification tool, comprising 23 questions about classical and lifestyle cardiovascular risk factors, was completed by 4149 individuals aged 40–69 years (median age 53.0 [47.0; 60.0] years; 78 % women). Among the cardiovascular risk factors, 40.9 % reported hypercholesterolemia, 26.8 % hypertension, 17.3 % smoking, 5.8 % diabetes, 58.4 % physical inactivity, 19.4 % obesity, 33.7 % sleep less than 7 h/night, and 12.1 % had composite dietary risk factors. Most of the participants (89.9 %) referred having at least one of the eight cardiovascular risk factors. Women had 27 % higher odds of having at least one cardiovascular risk factor compared to men (OR = 1.27, 95 % CI [1.00, 1.60]). Participants aged 50–59 years also had higher odds of having at least one CV risk factor compared to those aged 40–49 years (OR = 1.35, 95 % CI [1.07, 1.70]). Conclusion: The RADICAL Study reveals a high prevalence of cardiovascular risk factors in adults without known cardiovascular disease. Beyond the relevance of traditional risk factors, such as hypercholesterolemia and hypertension, the results regarding physical activity, dietary and sleeping habits are concerning. A self-reported cardiovascular risk identification digital tool could be feasible and help to improve cardiovascular prevention.
- Endocrine disruptor DDE associated with a high-fat diet enhances the impairment of liver fatty acid composition in ratsPublication . Rodríguez-Alcalá, Luis M.; Sá, Carla; Pimentel, Lígia L.; Pestana, Diogo; Teixeira, Diana; Faria, Ana; Calhau, Conceição; Gomes, Ana M. P.The banned pesticide dichlorodiphenyltrichloroethane (DDT) and its main metabolite, p,p′-dichlorodiphenyldichloroethylene (DDE), are commonly found in the food chain and in all tissues of living organisms. DDE is associated with metabolic diseases acting as an endocrine disruptor and more recently with the obesity pandemic. This study focuses on using fatty acid analysis to relate DDE exposure and metabolic dysfunction: liver and adipose tissue (visceral and subcutaneous) composition from male Wistar rats fed a standard (STD) or high-fat (HF) diet versus the addition of DDE in water. DDE exposure increased liver levels of palmitic, stearic, oleic, trans fatty, and linoleic acids having altered the n6 and n3 pathways leading to high concentrations of arachidonic acid and DHA (C22:6 n3). The results of this study confirm the close relationship between this pesticide metabolite and hepatic lipid dysfunction, underscoring its role as an emerging target for the prevention and therapy of nonalcoholic fatty liver disease (NAFLD).
- The iogeneration intervention study at Lisbon: iodine status and iodised salt consumption in school-aged childrenPublication . Mota, Inês Barreiros; Pestana, Diogo; Marques, Cláudia; Teixeira, Diana; Morais, Juliana; Faria, Ana; Cortez, Ana Paula Bidutte; Quaresma, Raquel; Pinto, Edgar; Fernandes, Virgínia Cruz; Maia, Maria Luz; Rosário, André; Keating, Elisa; Leite, João Costa; Almeida, Agostinho; Azevedo, Luís; Lima, Rui Matias; Calhau, Conceição