Browsing by Author "Mota-Rolim, Sergio"
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- Long COVID as a risk factor for hypersomnolence and fatigue: insights from the 2nd International Covid Sleep Study Collaboration (ICOSS-2)Publication . Sarkanen, Tomi; Merikanto, Ilona; Bjorvatn, Bjorn; Chung, Frances; Holzinger, Brigitte; Morin, Charles M.; Penzel, Thomas; Gennaro, Luigi de; Wing, Yun Kwok; Benedict, Christian; Xue, Pei; Reis, Cátia; Korman, Maria; Landtblom, Anne-Marie; Matsui, Kentaro; Hrubos-Strom, Harald; Mota-Rolim, Sergio; Nadorff, Michael R.; Berezin, Linor; Liu, Yaping; Scarpelli, Serena; Brandão, Luiz E. M.; Cedernaes, Jonathan; Partinen, Eemil; Bolstad, Courtney J.; Plazzi, Giuseppe; Espie, Colin A.; Partinen, Markku; Dauvilliers, YvesBackground: Hypersomnolence, defined as excessive daytime sleepiness (EDS), excessive quantity of sleep (EQS), sleep inertia, and fatigue reduce quality of life. We assessed associations of the COVID-19 pandemic, infection without long-term sequalae (short COVID, SC), and long COVID (LC) on hypersomnolence and fatigue in a large population across different countries. Methods: As part of an online questionnaire (ICOSS-2), we assessed EDS via the Epworth Sleepiness Scale (ESS), fatigue via Fatigue Severity Scale (FSS), and sleep duration at night and per 24 h. We also assessed the associations with EDS, sleep inertia, fatigue and napping by their frequencies, during the pandemic in COVID-negative, SC and LC participants. Results: The final cohort comprised 13,656 participants (69.1 % women, 42.7 ± 16.6 years), with 12.4 % classified SC and 7.5 % LC. ESS scores were higher in LC (9.16, 95 % CI [8.78, 9.53]) compared to SC (7.26, [6.97, 7.55]) and COVID-negative (6.53, [6.43, 6.63]). LC also had higher odds of ESS>10 (OR 1.58, [1.18,2.09]). FSS scores were higher in LC (median 51, IQR 39–59) than SC (34, 25–44) and COVID-negative (35, 25–45), with LC having 2.22 higher odds of severe fatigue. LC cases also reported more EQS (?10/24 h) than COVID-negative. Worsening of EDS, fatigue, sleep inertia, and napping was reported during pandemic to a greater extent in LC. Conclusions: LC was associated with higher levels of hypersomnolence and fatigue than in SC or COVID-negative participants, highlighting the need for interventions and future research focusing on sleep symptoms and their relation to long-term health outcomes.
- Lucid dreaming: not just awareness, but agencyPublication . Ableidinger, Severin; DeGennaro, Luigi; Mota-Rolim, Sergio; Scarpelli, Serena; Bolstad, Courtney J.; Bjorvatn, Bjørn; Espie, Colin A.; Dauvilliers, Yves; Korman, Maria; Landtblom, Anne Marie; Plazzi, Giuseppe; Matsui, Kentaro; Yordanova, Juliana; Bjelajac, Adrijana Koscec; Reis, Cátia; Chung, Frances; Merikanto, Ilona; Wing, Yun K.; Partinen, Markku; Macêdo, Tainá; Nadorff, Michael R.; Holzinger, BrigitteDuring lucid dreaming (LD), dreamers are aware that they are dreaming and may be able to influence the oneiric content. There has been recent debate about the relative importance of the ability to influence the dream and having agency over the pure awareness of dreaming. To underline this, we examined the associations of lucid dreams without agency (LD?Ag) and lucid dreams with agency (LD + Ag) to sleep and mental health problems and long COVID during the pandemic. We collected data in 16 countries on four continents from May to December 2021 on 10,715 subjects. Logistic regression was performed to predict LD?Ag and LD + Ag, with a sample of 8133 participants. We found that 30% of the participants frequently knew they were dreaming during the pandemic. About half of those (17%) reported that they could influence their dreams. Female gender and anxiety symptoms were negatively associated with LD + Ag. Dream recall, nightmares, insomnia, dream enactment behaviour (DEB), sleep vocalisation, short and long COVID and PTSD were positively associated with LD + Ag. Old age, dream recall, nightmares and anxiety symptoms were positively associated with LD?Ag, while short sleep length, being an evening type, and short COVID were negatively associated with LD?Ag. The different associations for LD?Ag and LD + Ag suggest that they may be distinct sleep states. This is also the first study to show that both COVID-19 and long COVID are associated with LD.
- Sleep symptoms are essential features of long-COVID – comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II)Publication . Merikanto, Ilona; Dauvilliers, Yves; Chung, Frances; Wing, Yun Kwok; de Gennaro, Luigi; Holzinger, Brigitte; Bjorvatn, Bjørn; Morin, Charles M.; Penzel, Thomas; Benedict, Christian; Koscec Bjelajac, Adrijana; Chan, Ngan Yin; Espie, Colin A.; Hrubos-Strøm, Harald; Inoue, Yuichi; Korman, Maria; Landtblom, Anne Marie; Léger, Damien; Matsui, Kentaro; Mota-Rolim, Sergio; Nadorff, Michael R.; Plazzi, Giuseppe; Reis, Cátia; Yordanova, Juliana; Partinen, MarkkuMany people report suffering from post-acute sequelae of COVID-19 or “long-COVID”, but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18–99 years from 16 countries of Asia, Europe, North America and South America (May–Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute sequelae of COVID-19 has a clinical relevance when diagnosing and treating long-COVID.
- The association of insomnia with long COVID: an international collaborative study (ICOSS-II)Publication . Chen, Si Jing; Morin, Charles M.; Ivers, Hans; Wing, Yun Kwok; Partinen, Markku; Merikanto, Ilona; Holzinger, Brigitte; Espie, Colin A.; De Gennaro, Luigi; Dauvilliers, Yves; Chung, Frances; Yordanova, Juliana; Vidović, Domagoj; Reis, Catia; Plazzi, Giuseppe; Penzel, Thomas; Nadorff, Michael R.; Matsui, Kentaro; Mota-Rolim, Sergio; Leger, Damien; Landtblom, Anne Marie; Korman, Maria; Inoue, Yuichi; Hrubos-Strøm, Harald; Chan, Ngan Yin; Bjelajac, Adrijana Koscec; Benedict, Christian; Bjorvatn, BjørnObjective: There is evidence of a strong association between insomnia and COVID-19, yet few studies have examined the relationship between insomnia and long COVID. This study aimed to investigate whether COVID-19 patients with pre-pandemic insomnia have a greater risk of developing long COVID and whether long COVID is in turn associated with higher incident rates of insomnia symptoms after infection. Methods: Data were collected cross-sectionally (May–Dec 2021) as part of an international collaborative study involving participants from 16 countries. A total of 2311 participants (18–99 years old) with COVID-19 provided valid responses to a web-based survey about sleep, insomnia, and health-related variables. Log-binomial regression was used to assess bidirectional associations between insomnia and long COVID. Analyses were adjusted for age, sex, and health conditions, including sleep apnea, attention and memory problems, chronic fatigue, depression, and anxiety. Results: COVID-19 patients with pre-pandemic insomnia showed a higher risk of developing long COVID than those without pre-pandemic insomnia (70.8% vs 51.4%; adjusted relative risk [RR]: 1.33, 95% confidence interval [CI]: 1.07–1.65). Among COVID-19 cases without pre-pandemic insomnia, the rates of incident insomnia symptoms after infection were 24.1% for short COVID cases and 60.6% for long COVID cases (p <.001). Compared with short COVID cases, long COVID cases were associated with an increased risk of developing insomnia symptoms (adjusted RR: 2.00; 95% CI: 1.50–2.66). Conclusions: The findings support a bidirectional relationship between insomnia and long COVID. These findings highlight the importance of addressing sleep and insomnia in the prevention and management of long COVID.