Browsing by Author "Mariano, Estevam Nascimento"
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- Candida-associated denture stomatitis : the molecular mechanisms in response to antimicrobial therapyPublication . Mariano, Estevam Nascimento; Duarte, Ana Sofia Direito dos Santos; Fonseca, Patrícia Alexandra Barroso da; Silva, Raquel Monteiro Marques daIntroduction: Oral candidasis, a fungal infection caused mainly by Candida albicans, has different clinical manifestations, affecting the oral region and Other parts of the body, especially in immunocompromised patients. The diagnosis of this infection must be precise and therapeutic Options are essential. Current treatments includes azoles, polyenes and echinocandins. However, antifungal resistance, especially to azole, has made treatment difficult, highlighting the importance of new therapeutic alternatives. Materials and Methods: The selection of articles for this systematic review was carried out independently by researchers, following the PRISMA standard and using the PICO model in order to define the research question. This search was conducted in March 2024 in PubMed/MEDLINE, Scopus and WebOfScience databases, using MeSH terms. Inclusion and exclusion criteria were defined in order to guarantee the relevance of the studies. The data was extracted and organized using the Rayyan platform for selection and analysis of the articles. Results: A total of 44 articles were selected and organized in alphabetical order to collect general data, including the year of publication, title, and objectives. The evaluation focused on the prevalence of species, genes, and therapeutics in C. albicans, as well as the prevalence of genes and therapeutics in C. glabrata and C. dubliniensis. Objectives: The aim of this study was to gather scientific evidence on the mechanisms of fungal resistance, focusing on the molecular alterations associated with antimicrobial therapies and assessing the prevalence of these alterations. Conclusion: Oral candidiasis is currently proving to be an increasing challenge because of the ability of the Candida species to acquire resistance. Genes suc as Erg11, FKS1, FKS2, MDR1, CDR1 and CDR2 have been described as related to resistance. In addition, therapeutic approaches such Photodynamic Therapy mediated by curcumin, Histatin 5, Caffeic Acid Phenethyl Ester and Tidiazurin have shown potential in combating these infections.