Browsing by Author "Furtini, Josy Anteveli Osajima"
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- Antibacterial and healing effect of chicha gum hydrogel (sterculia striata) with nerolidolPublication . Lima, Idglan Sá de; Ferreira, Maria Onaira Gonçalves; Barros, Esmeralda Maria Lustosa; Rizzo, Marcia dos Santos; Santos, Jailson de Araújo; Ribeiro, Alessandra Braga; Furtini, Josy Anteveli Osajima; Silva-Filho, Edson C.; Estevinho, Leticia M.Chicha gum is a natural polymer obtained from the Sterculia striata plant. The hydroxyl groups of its structure have a chemical affinity to form hydrogels, which favors the association with biologically active molecules, such as nerolidol. This association improves the biological properties and allows the material to be used in drug delivery systems. Chicha gum hydrogels associated with nerolidol were produced at two concentrations: 0.01 and 0.02 g mL−1. Then, the hydrogels were characterized by thermogravimetry (TG), Fourier Transform Infrared spectroscopy (FTIR), and rheological analysis. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coli. The cytotoxicity was evaluated against Artemia salina. Finally, an in vivo healing assay was carried out. The infrared characterization indicated that interactions were formed during the gel reticulation. This implies the presence of nerolidol in the regions at 3100–3550 cm−1. The rheological properties changed with an increasing concentration of nerolidol, which resulted in less viscous materials. An antibacterial 83.6% growth inhibition effect was observed using the hydrogel with 0.02 g mL−1 nerolidol. The in vivo healing assay showed the practical activity of the hydrogels in the wound treatment, as the materials promoted efficient re-epithelialization. Therefore, it was concluded that the chicha hydrogels have the potential to be used as wound-healing products.
- Cytotoxic and antibacterial activity of chichá gum hydrogel associated with nerolidolPublication . Lima, Idglan Sá; Gonçalves, Maria Onaira Ferreira; Silva, Albert Santos; Ribeiro, Alessandra Braga; Barreto, Humberto Medeiros; Furtini, Josy Anteveli Osajima; Filho, Edson Cavalcanti da SilvaChichá gum is a polysaccharide from the Sterculia striata plant, with a chemical structure composed of hydroxyl groups, which favor the formation of hydrogels, enabling the association with other materials to improve their biological properties and as drug delivery systems. Hydrogels were produced from chichá gum associated with nerolidol in concentrations of 1 and 2%, cytotoxicity was evaluated against Artemia salina. The hydrogels were tested against the strains Staphylococcus aureus and Escherichia coli, by the direct contact test. the material showed no toxic activity and an antibacterial effect was observed with 83.6% growth inhibition with the use of the hydrogel with 2% nerolidol. It concludes that the materials produced have the potential to be used in the future as products with good antibacterial properties.