Browsing by Author "Fonseca, M."
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- Analyzing the potential of selected gut commensal strains to produce antimicrobial peptides: phenotypic and in silico approachesPublication . Fonseca, M.; Machado, D.; Vedor, R.; Andrade, J. C.; Gomes, A. M.; Barbosa, J. C.The World Health Organization estimates that the number of antibiotic resistance-related deaths could reach 10 million by 2050 [1]. Given the dynamics and high diversity of microorganisms that inhabit the gastrointestinal tract, this is the ideal place to discover new antimicrobial peptides (AMP) to replace traditional antibiotics [2]. Among the most extensively studied members are the commensal strains Akkermansia muciniphila DSM 22959 and Faecalibacterium duncaniae DSM 17677, which are reported to have a beneficial impact on intestinal health [3;4]. Antimicrobial peptides are small molecules that act as the first line of defense against microbial invaders, playing a vital role in the innate immune system [5]. One approach to identify new strategies to combat antimicrobial resistance is to evaluate the ability of these bacteria to produce AMP.
- Hydrophobicity and aggregation properties of gut commensals faecalibacterium duncaniae DSM 17677 and akkermansia muciniphila DSM 22959Publication . Fonseca, M.; Machado, D.; Vedor, R.; Barbosa, J. C.; Andrade, J. C.; Gomes, A. M.Probiotics have been emerging as a promising approach to prevent and control foodborne diseases [1]. In the last years, the bacterial species isolated from gut microbiota, such as Faecalibacterium spp. and Akkermansia muciniphila, have been proposed as novel probiotic candidates [2]. The cell surface hydrophobicity, auto-aggregation and co-aggregation with pathogens are considered desirable characteristics of probiotic strains and these properties may be used in preliminary screening to identify potential probiotic microorganisms appropriate for human or animal use [3].
- Potential of Akkermansia muciniphila DSM 22959 and Faecalibacterium duncaniae DSM 17677 as live biotherapeutics for intestinal infectionsPublication . Machado, D.; Vedor, R.; Fonseca, M.; Bento, M.; Barbosa, J. C.; Almeida, D.; Andrade, J. C.; Gomes, A. M.