Percorrer por autor "Filippis, Ana Maria Bispo de"
A mostrar 1 - 6 de 6
Resultados por página
Opções de ordenação
- Correction to “Exploring the urban arbovirus landscape in Rio de Janeiro, Brazil: transmission dynamics and patterns of disease spread” The Lancet Regional Health – Americas 2024;35: 100786 (The Lancet Regional Health - Americas (2024) 35, (S2667193X24001133), (10.1016/j.lana.2024.100786))Publication . Schuab, Gabriel; Tosta, Stephane; Moreno, Keldenn; Fonseca, Vagner; Santos, Luciane Amorim; Slavov, Svetoslav Nanev; Kashima, Simone; Ciccozzi, Massimo; Lourenço, José; Cella, Eleonora; Oliveira, Carla de; Cavalcanti, Andréa Cony; Alcantara, Luiz Carlos Junior; Bruycker-Nogueira, Fernanda de; Filippis, Ana Maria Bispo de; Giovanetti, MartaThe authors wish to correct the data sharing statement, acknowledgments and include a citation for the published work and apologise for any inconvenience the error may have caused.
- Dengue virus transmission in Italy: historical trends up to 2023 and a data repository into the futurePublication . Branda, Francesco; Nakase, Taishi; Maruotti, Antonello; Scarpa, Fabio; Ciccozzi, Alessandra; Romano, Chiara; Peletto, Simone; Filippis, Ana Maria Bispo de; Alcantara, Luiz Carlos Junior; Marcello, Alessandro; Ciccozzi, Massimo; Lourenço, José; Giovanetti, MartaDengue virus circulation is on the rise globally, with increased epidemic activity in previously unaffected countries, including within Europe. In 2023, global dengue activity peaked, and Italy reported the highest number of dengue cases and local chains of transmission to date. By curating several sources of information, we introduce a novel data repository focused on dengue reporting in Italy. We integrate data from such a repository with other geographic, genomic and climatic spatiotemporal data to present an overview of transmission patterns of the past eight years related to circulating viral lineages, geographic distribution, hotspots of reporting, and the theoretical contribution of local climate. The novel data repository can contribute to a better understanding of an evolving epidemiological scenario in Italy, with the potential to inform reassessment and planning of adequate national and European public health strategies to manage the emergence of the dengue virus.
- Exploring the urban arbovirus landscape in Rio de Janeiro, Brazil: transmission dynamics and patterns of disease spreadPublication . Schuab, Gabriel; Tosta, Stephane; Moreno, Keldenn; Fonseca, Vagner; Santos, Luciane Amorim; Slavov, Svetoslav Nanev; Kashima, Simone; Ciccozzi, Massimo; Lourenço, José; Cella, Eleonora; Oliveira, Carla de; Cavalcanti, Andréa Cony; Alcantara, Luiz Carlos Junior; Bruycker-Nogueira, Fernanda de; Filippis, Ana Maria Bispo de; Giovanetti, MartaBackground: This study focuses on urban arboviruses, specifically dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV), which pose a significant public health challenge in Rio de Janeiro state, Southeast Brazil. In our research, we highlight critical findings on the transmission dynamics of these arboviruses in Rio de Janeiro, identifying distinct patterns of disease spread. Methods: By combining genomic data with case reports from the Brazilian Ministry of Health, we have analysed the phylogenetics, prevalence and spatial distribution of these endemic viruses within the state. Findings: Our results revealed sustained DENV transmission primarily in the northern part of the state, a significant ZIKV epidemic in 2016 affecting all mesoregions, and two major CHIKV outbreaks in 2018 and 2019, predominantly impacting the northern and southern areas. Our analysis suggests an inverse relationship between arboviral case incidence and urban density, with less populous regions experiencing higher transmission rates, potentially attributed to a complex interplay of factors such as the efficacy of vector control measures, environmental conditions, local immunity levels, and human mobility. Furthermore, our investigation unveiled distinct age and gender trends among affected individuals. Notably, dengue cases were predominantly observed in young adults aged 32, while chikungunya cases were more prevalent among individuals over 41. In contrast, cases of ZIKV were concentrated around the 33-year age group. Intriguingly, females accounted for nearly 60% of the cases, suggesting a potential gender-based difference in infection rates. Interpretation: Our findings underscore the complexity of arbovirus transmission and the need for interventions tailored to different geographical mesoregions. Enhanced surveillance and genomic sequencing will be essential for a deeper, more nuanced understanding of regional arbovirus dynamics. Identifying potential blind spots within the state will be pivotal for developing and implementing more effective public health strategies, specifically designed to address the unique challenges posed by these viruses throughout the state. Funding: This study was supported by the National Institutes of Health USA grant U01 AI151698 for the United World Arbovirus Research Network (UWARN) and the CRP-ICGEB RESEARCH GRANT 2020 Project CRP/BRA20-03.
- Integrated analyses of the transmission history of SARS-CoV-2 and its association with molecular evolution of the virus underlining the pandemic outbreaks in Italy, 2019-2023Publication . Cella, Eleonora; Fonseca, Vagner; Branda, Francesco; Tosta, Stephane; Moreno, Keldenn; Schuab, Gabriel; Ali, Sobur; Slavov, Svetoslav Nanev; Scarpa, Fabio; Santos, Luciane Amorim; Kashima, Simone; Wilkinson, Eduan; Tegally, Houriiyah; Mavian, Carla; Borsetti, Alessandra; Caccuri, Francesca; Salemi, Marco; Oliveira, Tulio de; Azarian, Taj; Filippis, Ana Maria Bispo de; Alcantara, Luiz Carlos Junior; Ceccarelli, Giancarlo; Caruso, Arnaldo; Colizzi, Vittorio; Marcello, Alessandro; Lourenço, José; Ciccozzi, Massimo; Giovanetti, MartaBackground: Italy was significantly affected by the COVID-19 pandemic, experiencing multiple waves of infection following the sequential emergence of new variants. Understanding the transmission patterns and evolution of SARS-CoV-2 is vital for future preparedness. Methods: We conducted an analysis of viral genome sequences, integrating epidemiological and phylodynamic approaches, to characterize how SARS-CoV-2 variants have spread within the country. Results: Our findings indicate bidirectional international transmission, with Italy transitioning between importing and exporting the virus. Italy experienced four distinct epidemic waves, each associated with a significant reduction in fatalities from 2021 to 2023. These waves were primarily driven by the emergence of VOCs such as Alpha, Delta, and Omicron, which were reflected in observed transmission dynamics and effectiveness of public health measures. Conclusions: The changing patterns of viral spread and variant prevalence throughout Italy's pandemic response underscore the continued importance of flexible public health strategies and genomic surveillance, both of which are crucial for tracking the evolution of variants and adapting control measures effectively to ensure preparedness for future outbreaks.
- North–south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican RepublicPublication . Miguel, Isaac; Feliz, Edwin P.; Agramonte, Robinson; Martinez, Pedro V.; Vergara, Carlos; Imbert, Yvonne; Cruz, Lucia De la; Castro, Nurys de; Cedano, Odalis; Paz, Yamilka De la; Fonseca, Vagner; Santiago, Gilberto A.; Muñoz-Jordán, Jorge L.; Peguero, Armando; Paulino-Ramírez, Robert; Grubaugh, Nathan D.; Filippis, Ana Maria Bispo de; Alcantara, Luiz Carlos Junior; Rico, Jairo Mendez; Lourenço, José; Franco, Leticia; Giovanetti, MartaBackground: Dengue fever remains a significant public health challenge in tropical and subtropical regions, with its transmission dynamics being influenced by both environmental factors and human mobility. The Dominican Republic, a biodiversity hotspot in the Caribbean, has experienced recurrent dengue outbreaks, yet detailed understanding of the virus's transmission pathways and the impact of climatic factors remains limited. This study aims to elucidate the recent transmission dynamics of the dengue virus (DENV) in the Dominican Republic, utilizing a combination of genomic sequencing and epidemiological data analysis, alongside an examination of historical climate patterns. Methods: We conducted a comprehensive study involving the genomic sequencing of DENV samples collected from patients across different regions of the Dominican Republic over a two-year period. Phylogenetic analyses were performed to identify the circulation of DENV lineages and to trace transmission pathways. Epidemiological data were integrated to analyze trends in dengue incidence and distribution. Additionally, we integrated historical climate data spanning several decades to assess trends in temperature and their potential impact on DENV transmission potential. Results: Our results highlight a previously unknown north–south transmission pathway within the country, with the co-circulation of multiple virus lineages. Additionally, we examine the historical climate data, revealing long-term trends towards higher theoretical potential for dengue transmission due to rising temperatures. Conclusion: This multidisciplinary study reveals intricate patterns of dengue virus transmission in the Dominican Republic, characterized by the co-circulation of multiple DENV lineages and a novel transmission pathway. The observed correlation between rising temperatures and increased dengue transmission potential emphasizes the need for integrated climate-informed strategies in dengue control efforts. Our findings offer critical insights for public health authorities in the Dominican Republic and similar settings, guiding resource allocation and the development of preparedness strategies to mitigate the impacts of climate change on dengue transmission.
- Reemergence of yellow fever virus in forest and periurban settings in BrazilPublication . Andrade, Valnete das Graças Dantas; Adelino, Talita Émile Ribeiro; Fonseca, Vagner; Moreno, Keldenn Melo Farias; Tomé, Luiz Marcelo Ribeiro; Pereira, Luiz Augusto; La-Roque, Debora Glenda Lima de; Filippis, Ana Maria Bispo de; Ramos, Daniel Garkauskas; Ramalho, Dario Brock; Furtado, Kátia Cristina de Lima; Borges, Gleissy Adriane Lima; Martins, Livia Caricio; Frutuoso, Livia C. V.; Lamounier, Ludmila Oliveira; Guimarães, Natália Rocha; Barros, Patrícia Miriam Sayuri Sato; Almeida, Priscila Souza de; Silva, Paulo Eduardo de Souza da; Pinheiro, Rodrigo Giesbrecht; Stabeli, Rodrigo Guerino; Chagas, Shirley Moreira da Silva; Pedroso, Sílvia Helena Sousa Pietra; Kashima, Simone; Penante, Solange Gonçalves; Oliveira, Marília Santini de; Silva, Vinicius Lemes da; Voorhis, Wesley C. Van; Holmes, Edward C.; Lourenço, José; Iani, Felipe Campos de Melo; Júnior, Alberto Simões Jorge; Giovanetti, Marta; Alcantara, Luiz Carlos JuniorBackground: Yellow fever virus remains a major public health threat in Brazil, where recent resurgence risks affecting both forest and periurban populations. Understanding viral movement across ecological settings is critical to support early detection and prevent outbreaks. Methods: We performed genomic surveillance in two Brazilian states, a northern Amazon region and a southeastern region, between 2023 and 2025. Human and non-human primate samples were collected across forest, rural, and urban environments. Viral genomes were generated and analyzed using phylogenetic, phylogeographic, and temporal approaches to reconstruct viral transmission patterns. Results: Here, we show evidence of continued yellow fever virus circulation and diversification in distinct ecological settings. We generate 25 genomes from humans and non-human primates, including the first human-derived genomes from the Amazon region. All genomes fall within the South American lineage. We identify one cluster in the Amazon region consistent with undetected viral persistence and reemergence, and a second cluster in the southeast associated with reintroduction followed by sustained local transmission. Conclusions: These findings demonstrate ongoing yellow fever virus activity in Brazil, with forest regions serving as reservoirs for reemergence and periurban areas supporting continued spread. Strengthened genomic and epizootic surveillance is required to detect viral expansion early and inform targeted prevention strategies across Brazil and the Americas.