Browsing by Author "Ferreira, Mariana de Almeida Baraças"
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- Do clear aligners release toxic chemicals? : a systematic reviewPublication . Ferreira, Mariana de Almeida Baraças; Lopes, Pedro André Ferreira Campos; Gomes, Ana Teresa Peixoto de CamposClear aligners are a modern orthodontic solution designed to address dental malocclusions discreetly and effectively. In terms of clinical side effects, the most reported issues among aligner users are mild irritation of the oral mucosa, localized inflammation, and hypersensitivity. The use of advanced polymer materials in clear aligners, such as polyurethane and PET-G, has gained widespread acceptance due to their mechanical properties, biocompatibility and aesthetic appeal. However, concerns persist regarding their potential to release chemical compounds. The goal of this work is to understand the impact of the toxicity of clear aligners on oral cavity of orthodontic patients. An extensive systematic search was conducted in electronic databases PubMed, Scopus and Cochrane, to identify articles with relevant data. This systematic review was conducted following the Preferred Reporting Items for Systematic reviews and Meta-analysis guidelines to answer a question formulated according to the Population, Intervention, Comparison and Outcomes strategy. Four hundred and thirteen articles potentially relevant were identified and after applying PRISMA guidelines and inclusion/exclusion criteria, seven articles were included in this review. The results suggest that clear aligners are generally safe, but concerns remain regarding the chemical leaching of thermoplastic materials, bacterial accumulation due to reduced saliva flow, and mild inflammatory responses. This review emphasizes that although most materials are biocompatible, some exhibit moderate cytotoxicity, with the potential to impact these patients9 oral health, underscoring the need for continued research and improvements in material composition.