Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.14/17605
Título: Biodegradation of sulfamethoxazole and other sulfonamides byAchromobacter denitrificans PR1
Autor: Reis, Patrícia J. M.
Reis, Ana C.
Rickenc, Benjamin
Kolvenbachc, Boris A.
Manaia, Célia
Corvinic, Philippe F.X.
Nunesa, Olga C.
Palavras-chave: Pharmaceutical
Antibiotic resistancea
Data: 2014
Citação: REIS, Patrícia J. M. [et al.] - Biodegradation of sulfamethoxazole and other sulfonamides byAchromobacter denitrificans PR1. Journal of Hazardous Materials. ISSN 0304-3894. Vol. 280 (2014), p. 741–749
Resumo: tThis study aimed to isolate and characterize a microbial culture able to degrade sulfonamides. Sul-famethoxazole (SMX)-degrading microorganisms were enriched from activated sludge and wastewater.The resultant mixed culture was composed of four bacterial strains, out of which only Achromobacterdenitrificans PR1 could degrade SMX. This sulfonamide was used as sole source of carbon, nitrogen andenergy with stoichiometric accumulation of 3-amino-5-methylisoxazole. Strain PR1 was able to removeSMX at a rate of 73.6 ± 9.6 molSMX/gcell dry weighth. This rate more than doubled when a supplement ofamino acids or the other members of the mixed culture were added. Besides SMX, strain PR1 was able todegrade other sulfonamides with anti-microbial activity. Other environmental Achromobacter spp. couldnot degrade SMX, suggesting that this property is not broadly distributed in members of this genus.Further studies are needed to shed additional light on the genetics and enzymology of this process.
Peer review: yes
URI: http://hdl.handle.net/10400.14/17605
Aparece nas colecções:CBQF - Artigos em revistas internacionais com Arbitragem / Papers in international journals with Peer-review

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