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Advisor(s)
Abstract(s)
In this study, we investigated the b-lactamase-encoding genes responsible for
b-lactam resistance phenotypes detected among 56 Gram-negative isolates
(Gamma- and Alpha-proteobacteria) recovered from wastewater, urban streams,
and drinking water. The b-lactam resistance mechanisms detected in 36 isolates
comprised the presence of class A (blaTEM-1, blaSHV-1, blaSHV-11, blaGES-5), class B
(ImiS, L1), class C (blaCMY-2, blaCMY-34, blaCMY-65, blaCMY-89, blaCMY-90, blaACC-5,
blaACT-13), and class D (blaOXA-309)b-lactamase-encoding genes, some variants
described for the first time here. Notably, the results showed antimicrobial
resistance genes related not only to commonly used antibiotics, but also to
carbapenems, providing the first description of a GES-5-producing Enterobacteriaceae.
The importance of ubiquitous bacteria thriving in aquatic environments
as reservoirs or carriers of clinically relevant resistance determinants was
confirmed, and the need to monitor water habitats as potential sources for the
emergence and/or spread of antibiotic resistance in the environment was
highlighted.
Description
Keywords
Water Ubiquitous bacteria B-lactamase GES-5 Antibiotic resistance
Pedagogical Context
Citation
MANAGEIRO, Vera ...[et al.] - GES-5 among the b-lactamases detected in ubiquitous bacteria isolated from aquatic environment samples. FEMS Microbiology Letters. ISSN 1574-6968. Vol. 351 (2014), p. 64–69
Publisher
Federation of European Microbiological Societies.