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Advisor(s)
Abstract(s)
The nutritional environment during embryonic, fetal and neonatal development plays a crucial role in
the offspring’s risk of developing diseases later in life. Although non-nutritive sweeteners (NNS) provide
sweet taste without contributing to energy intake, animal studies showed that long-term consumption
of NSS, particularly aspartame, starting during the perigestational period may predispose the offspring to
develop obesity and metabolic syndrome later in life. In this paper, we review the impact of NNS exposure
during the perigestational period on the long-term disease risk of the offspring, with a particular focus on
metabolic diseases. Some mechanisms underlying NNS adverse metabolic effects have been proposed,
such as an increase in intestinal glucose absorption, alterations in intestinal microbiota, induction of
oxidative stress and a dysregulation of appetite and reward responses. The data reviewed herein suggest
that NNS consumption by pregnant and lactating women should be looked with particular caution and
requires further research.
Description
Keywords
Non-nutritive sweeteners Pregnancy Fetal programming Metabolic syndrome
Pedagogical Context
Citation
ARAÚJO, João Ricardo ; MARTE, Fátima ; KEATING, Elisa - Exposure to non-nutritive sweeteners during pregnancy and lactation: impact in programming of later in life metabolic diseases in the progeny later in life. Reproductive Toxicology. ISSN 0890-6238. Vol. 49 (2014), p. 196-201
Publisher
Elsevier