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Thermal annealed silk fibroin membranes for periodontal guided tissue regeneration

2019Journal article Restricted access
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dc.contributor.authorGeão, Catarina
dc.contributor.authorCosta-Pinto, Ana R.
dc.contributor.authorCunha-Reis, Cassilda
dc.contributor.authorRibeiro, Viviana P.
dc.contributor.authorVieira, Sílvia
dc.contributor.authorOliveira, Joaquim M.
dc.contributor.authorReis, Rui L.
dc.contributor.authorOliveira, A. L.
dc.date.accessioned2019-03-13T15:09:19Z
dc.date.available2019-03-13T15:09:19Z
dc.date.issued2019
dc.description.abstractGuided tissue regeneration (GTR) is a surgical procedure applied in the reconstruction of periodontal defects, where an occlusive membrane is used to prevent the fast-growing connective tissue from migrating into the defect. In this work, silk fibroin (SF) membranes were developed for periodontal guided tissue regeneration. Solutions of SF with glycerol (GLY) or polyvinyl alcohol (PVA) where prepared at several weight ratios up to 30%, followed by solvent casting and thermal annealing at 85 °C for periods of 6 and 12 h to produce high flexible and stable membranes. These were characterized in terms of their morphology, physical integrity, chemical structure, mechanical and thermal properties, swelling capability and in vitro degradation behavior. The developed blended membranes exhibited high ductility, which is particular relevant considering the need for physical handling and adaptability to the defect. Moreover, the membranes were cultured with human periodontal ligament fibroblast cells (hPDLs) up to 7 days. Also, the higher hydrophilicity and consequent in vitro proteolytic degradability of these blends was superior to pure silk fibroin membranes. In particular SF/GLY blends demonstrated to support high cell adhesion and viability with an adequate hPDLs’ morphology, make them excellent candidates for applications in periodontal regeneration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGeão, C., Costa-Pinto, A. R., Cunha-Reis, C., Ribeiro, V. P., Vieira, S., Oliveira, J. M., … Oliveira, A. L. (2019). Thermal annealed silk fibroin membranes for periodontal guided tissue regeneration. Journal of Materials Science: Materials in Medicine, 30(2). https://doi.org/10.1007/s10856-019-6225-ypt_PT
dc.identifier.doi10.1007/s10856-019-6225-ypt_PT
dc.identifier.eid85061389267
dc.identifier.eissn0957-4530
dc.identifier.issn0957-4530
dc.identifier.pmid30747338
dc.identifier.urihttp://hdl.handle.net/10400.14/27087
dc.identifier.wos000458545200004
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationIF/00411/2013
dc.relationIF/00423/2012
dc.relationIF/01285/2015
dc.relationIF/00411/2013/CP1167
dc.relationBioengineered Silk Fibroin-Based Contructs with Potential for Osteochondral Tissue Regeneration
dc.titleThermal annealed silk fibroin membranes for periodontal guided tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBioengineered Silk Fibroin-Based Contructs with Potential for Osteochondral Tissue Regeneration
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F113806%2F2015/PT
oaire.citation.issue2
oaire.citation.titleJournal of Materials Science: Materials in Medicinept_PT
oaire.citation.volume30
oaire.fundingStream5876
oaire.fundingStreamOE
person.familyNameCunha Reis
person.familyNameRibeiro
person.familyNameVieira
person.familyNameOliveira
person.familyNameReis
person.givenNameCassilda
person.givenNameDr. Viviana
person.givenNameSílvia
person.givenNameJoaquim Miguel
person.givenNameRui L.
person.identifier231614
person.identifier832165
person.identifier.ciencia-idE718-0A09-A959
person.identifier.ciencia-id9414-CDFB-4371
person.identifier.ciencia-id0B16-8EF6-862A
person.identifier.ciencia-id6F11-C02E-8B6C
person.identifier.orcid0000-0001-6886-3900
person.identifier.orcid0000-0002-3679-0759
person.identifier.orcid0000-0002-6481-4500
person.identifier.orcid0000-0001-7052-8837
person.identifier.orcid0000-0002-4295-6129
person.identifier.ridA-3670-2019
person.identifier.ridH-8636-2012
person.identifier.ridA-8938-2008
person.identifier.scopus-author-id20336729000
person.identifier.scopus-author-id56104780500
person.identifier.scopus-author-id57202066972
person.identifier.scopus-author-id56861715700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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