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A new era for sterilization based on supercritical CO2 technology

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dc.contributor.authorRibeiro, Nilza
dc.contributor.authorSoares, Gonçalo C.
dc.contributor.authorSantos-Rosales, Víctor
dc.contributor.authorConcheiro, Angel
dc.contributor.authorAlvarez-Lorenzo, Carmen
dc.contributor.authorGarcía-González, Carlos A.
dc.contributor.authorOliveira, Ana L.
dc.date.accessioned2019-06-07T11:53:34Z
dc.date.available2019-06-07T11:53:34Z
dc.date.issued2019
dc.description.abstractThe increasing complexity in morphology and composition of modern biomedical materials (e.g., soft and hard biological tissues, synthetic and natural‐based scaffolds, technical textiles) and the high sensitivity to the processing environment requires the development of innovative but benign technologies for processing and treatment. This scenario is particularly applicable where current conventional techniques (steam/dry heat, ethylene oxide, and gamma irradiation) may not be able to preserve the functionality and integrity of the treated material. Sterilization using supercritical carbon dioxide emerges as a green and sustainable technology able to reach the sterility levels required by regulation without altering the original properties of even highly sensitive materials. In this review article, an updated survey of experimental protocols based on supercritical sterilization and of the efficacy results sorted by microbial strains and treated materials was carried out. The application of the supercritical sterilization process in materials used for biomedical, pharmaceutical, and food applications is assessed. The opportunity of supercritical sterilization of not only replace the above mentioned conventional techniques, but also of reach unmet needs for sterilization in highly sensitive materials (e.g., single‐use medical devices, the next‐generation biomaterials, and medical devices and graft tissues) is herein unveiled.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationRibeiro, N., Soares, G. C., Santos‐Rosales, V., Concheiro, A., Alvarez‐Lorenzo, C., García‐González, C. A., & Oliveira, A. L. (2019). A new era for sterilization based on supercritical CO 2 technology. Journal of Biomedical Materials Research Part B: Applied Biomaterials. https://doi.org/10.1002/jbm.b.34398pt_PT
dc.identifier.doi10.1002/jbm.b.34398pt_PT
dc.identifier.eid85077317980
dc.identifier.eissn1552-4981
dc.identifier.issn1552-4973
dc.identifier.pmid31132221
dc.identifier.urihttp://hdl.handle.net/10400.14/27731
dc.identifier.wos000505634000010
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationED431C 2016/008
dc.relationED431F 2016/010
dc.relation0245_IBEROS_1_E
dc.relationIF/00411/2013
dc.relationIF/00411/2013/CP1167
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relationSAF2017‐83118‐R
dc.relationRTI2018‐094131‐A‐I00
dc.subjectBiomedical materialspt_PT
dc.subjectDrug-medical device combination productspt_PT
dc.subjectDrug productspt_PT
dc.subjectSterilization efficacypt_PT
dc.subjectSterilization treatmentpt_PT
dc.subjectSupercritical carbon dioxidept_PT
dc.titleA new era for sterilization based on supercritical CO2 technologypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/Multi/50016/2013
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2013/PT
oaire.citation.titleJournal of Biomedical Materials Research Part B: Applied Biomaterialspt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRibeiro
person.familyNameSoares
person.familyNameSantos-Rosales
person.familyNameConcheiro
person.familyNameAlvarez-Lorenzo
person.familyNameGarcía-González
person.familyNameOliveira
person.givenNameNilza
person.givenNameGonçalo
person.givenNameVíctor
person.givenNameAngel
person.givenNameCarmen
person.givenNameCarlos A
person.givenNameAna
person.identifier1415634
person.identifier.ciencia-idD512-954A-1ED8
person.identifier.ciencia-idF31D-5595-860E
person.identifier.ciencia-id9D16-C1D8-7567
person.identifier.ciencia-id4713-31C8-A356
person.identifier.orcid0000-0002-9975-5432
person.identifier.orcid0000-0002-6694-2063
person.identifier.orcid0000-0002-5943-1839
person.identifier.orcid0000-0003-0507-049X
person.identifier.orcid0000-0002-8546-7085
person.identifier.orcid0000-0001-9542-3679
person.identifier.orcid0000-0001-8012-4203
person.identifier.ridJ-8109-2014
person.identifier.ridJ-8101-2014
person.identifier.ridK-2130-2014
person.identifier.ridJ-3404-2013
person.identifier.scopus-author-id24333106700
person.identifier.scopus-author-id7006298247
person.identifier.scopus-author-id7004396916
person.identifier.scopus-author-id26539915200
person.identifier.scopus-author-id55937245800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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