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Antimicrobial effect of chitosan against periodontal pathogens biofilms

dc.contributor.authorCosta, Eduardo M.
dc.contributor.authorSilva, Sara
dc.contributor.authorPina, Cristina
dc.contributor.authorTavaria, Freni K.
dc.contributor.authorPintado, Manuela
dc.date.accessioned2021-09-10T10:15:41Z
dc.date.available2021-09-10T10:15:41Z
dc.date.issued2014-01-01
dc.description.abstractOver the years authors have established that chitosan possesses significant antimicrobial activity against planktonic bacteria however, little is known about the effect of chitosan upon sessile microbial communities. The aim of this work was to assess the effect of chitosan against 5 periodontal pathogens, Porphyromonasgingivalis, Prevotellaintermedia, Prevotellabuccae, Tanerellaforsythensis and Aggregatibacter actinomycetemcomitans biofilm formation. The results obtained show that both high molecular weight and low molecular weight chitosan were capable of inhibiting biofilm formation and biofilm associated phenomena. Sub-MIC concentrations of chitosan inhibited single species biofilm formation up to 90% and dual species biofilms formation up to 80%. Furthermore analysis of the effect of chitosan upon quorum sensing showed inhibition values that reached 70% after 24h exposure to chitosan. The results obtained open new possibilities in the fight against biofilm formation in the oral cavity and the prevention of undesirable microbiological colonization following dental treatments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.15226/sojmid.2013.00114pt_PT
dc.identifier.issn2372-0956
dc.identifier.urihttp://hdl.handle.net/10400.14/34725
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiofilmpt_PT
dc.subjectChitosanpt_PT
dc.subjectDual speciespt_PT
dc.subjectSub-MICpt_PT
dc.subjectQuorum Sensingpt_PT
dc.titleAntimicrobial effect of chitosan against periodontal pathogens biofilmspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage6pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleSOJ Microbiology & Infectious Diseasespt_PT
oaire.citation.volume2pt_PT
person.familyNameCosta
person.familyNameKekhasharú Tavaria
person.familyNamePintado
person.givenNameEduardo
person.givenNameFreni
person.givenNameMaria Manuela
person.identifier456608
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id7004483898
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4f32e563-443f-4eff-8fea-e0916c20afa1
relation.isAuthorOfPublicatione42f563a-5b1e-4586-b302-efabe7ce07da
relation.isAuthorOfPublicationba387c7d-27c9-4016-895c-b35597e91ebc
relation.isAuthorOfPublication.latestForDiscoveryba387c7d-27c9-4016-895c-b35597e91ebc

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