Publication
Exploring the therapeutic potential of avocado oil: insights into obesity metabolism and immune regulation through in vitro models
| dc.contributor.author | Machado, Manuela | |
| dc.contributor.author | Costa, Eduardo M. | |
| dc.contributor.author | Silva, Sara | |
| dc.contributor.author | Gomes, Ana Maria | |
| dc.contributor.author | Pintado, Manuela | |
| dc.date.accessioned | 2024-12-13T18:03:31Z | |
| dc.date.available | 2024-12-13T18:03:31Z | |
| dc.date.issued | 2024-12-06 | |
| dc.description.abstract | Avocado oil boasts a compelling nutritional profile characterized by a richness of unsaturated fatty acids and key lipophilic compounds. This study aimed to explore the potential of avocado oil in obesity-related metabolic processes and immune responses modulation in in vitro cellular models. Results obtained unveiled avocado oil capacity to effectively regulate triglyceride accumulation in differentiated 3T3-L1 adipocytes, showcasing a remarkable five-fold increase in adipolysis rate at 15 mg/mL, and an increase in glucose uptake in insulin-stimulated cells. Furthermore, avocado oil exhibited significant immunomodulatory effects in IL-1β-stimulated Caco-2 cells, as it reduced IL-6 (by 11%) and IL-8 (by 12%) production at 10 mg/mL, while only a marginal uptick in TNF-α secretion was observed at the same concentration. These findings underscore the potential of avocado oil to be a beneficial component in functional foods and nutraceuticals targeted at obesity management. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.bcab.2024.103464 | pt_PT |
| dc.identifier.eid | 85211972274 | |
| dc.identifier.issn | 1878-8181 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/47516 | |
| dc.identifier.wos | 001391062100001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Lipid metabolism | pt_PT |
| dc.subject | Adipolysis | pt_PT |
| dc.subject | Anti-inflammatory | pt_PT |
| dc.subject | Nutraceuticals | pt_PT |
| dc.title | Exploring the therapeutic potential of avocado oil: insights into obesity metabolism and immune regulation through in vitro models | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Biocatalysis and Agricultural Biotechnology | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |